| 以主药溶解性能筛选体外经皮渗透试验中的接收液 |
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| 引用本文： | 魏敏,周莉玲,黄春青,江影莹. 以主药溶解性能筛选体外经皮渗透试验中的接收液[J]. 中药材, 2005, 28(4): 332-334 |
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| 作者姓名： | 魏敏 周莉玲 黄春青 江影莹 |
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| 作者单位： | 广州中医药大学,广州,510405 |
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| 基金项目： | 中国科学院资助项目，广东省博士启动基金 |
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| 摘 要： | 目的:筛选舒心贴剂中CVD体外经皮渗透试验的接收液.方法:采用异氰酸苯酯柱前衍生化RP-HPLC法,测定CVD在不同接收液中的饱和浓度,根据溶解性能筛选体外经皮渗透接收液.结果:七种接收液中以30%乙醇/生理盐水中CVD的浓度最高.结论:以主药溶解性能筛选体外经皮渗透试验的接收液,方法可靠、简便.
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| 关 键 词： | 经皮渗透 接收液 RP-HPLC法 |
| 修稿时间： | 2004-11-29 |
Selection of the Receptor Fluid Based on Main Drug''''s Dissolvability in the in-vitro Skin Permeation Study |
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| Wei Min,Zhou Liling,Huang Chunqing,Jiang Yingying. Selection of the Receptor Fluid Based on Main Drug''''s Dissolvability in the in-vitro Skin Permeation Study[J]. Journal of Chinese medicinal materials, 2005, 28(4): 332-334 |
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| Authors: | Wei Min Zhou Liling Huang Chunqing Jiang Yingying |
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| Affiliation: | Guangzhou University of TCM, Guangzhou 510405. |
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| Abstract: | OBJECTIVE: To select the receptor fluid used in the in-vitro skin permeation study of CVD from Shuxin transdermal patch. METHODS: The saturated concentration of CVD in different receptor fluid was determined by RP-HPLC with precolumn ultraviolet derivatization. And the selection of receptor fluid was based on main drug's dissolvability. RESULTS: The concentration of CVD in 30% ethanol/physiological saline was the highest among seven kinds of receptor fluid. CONCLUSION: The method used to select the receptor fluid based on main drug's dissolvability in the in-vitro skin permeation study is credible and convenient. |
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| Keywords: | Skin permeation Receptor fluid RP-HPLC |
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