Colposcopically directed biopsy, random cervical biopsy, and endocervical curettage in the diagnosis of cervical intraepithelial neoplasia II or worse |
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Authors: | Pretorius Robert G Zhang Wen-Hua Belinson Jerome L Huang Man-Ni Wu Ling-Ying Zhang Xun Qiao You-Lin |
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Affiliation: | Department of Obstetrics and Gynecology, Southern California Permanente Medical Group, Fontana, CA, USA. Robert.G.Pretorius@kp.org |
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Abstract: | OBJECTIVES: The purpose of this study was to determine the relative importance of colposcopically directed biopsy, random biopsy, and endocervical curettage (ECC) in diagnosing > or =cervical intraepithelial neoplasia (CIN) II.Study design During a screening study, 364 women with satisfactory colposcopy and > or =CIN II were diagnosed. All colposcopically detected lesions were biopsied. If colposcopy showed no lesion in a cervical quadrant, a random biopsy was obtained at the squamocolumnar junction in that quadrant. ECC was then performed. RESULTS: The diagnosis of > or =CIN II was made on a colposcopically directed biopsy in 57.1%, random biopsy in 37.4%, and ECC in 5.5% of women. The yield of > or =CIN II for random biopsy when cytology was high grade (17.6%) exceeded that when cytology was low grade (2.8%). One of 20 women diagnosed solely by ECC had invasive cancer. CONCLUSION: Even when colposcopy is satisfactory, ECC should be performed. If cytology is high grade, random biopsies should be considered. |
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Keywords: | Colposcopy Endocervical curettage Random cervical biopsy Cervical intraepithelial neoplasia |
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