地佐辛复合丙泊酚在双气囊小肠镜检查中的临床应用研究

目的:探讨地佐辛复合丙泊酚的麻醉镇痛作用在双气囊小肠镜检查中的安全性和有效性。方法:选择2010年9月-2012年12月来我院行双气囊小肠镜检查的患者60例,随机分为地佐辛组(A组)和对照组(B组),每组30例,A组先予0.1mg/kg地佐辛静脉注射,B组先予生理盐水5ml静脉注射,然后两组均予异丙酚0.8mg/kg静脉注射,再以3～5mg/(kg.h)的速度静脉泵注异丙酚维持麻醉,结束时A、B两组均不再追加任何药物。检查过程中监测两组患者MAP、HR、SpO2,观察术中反应,记录操作时间、丙泊酚总用量,记录术毕清醒后1min(T0)、5min(T1)、10min(T2)、20min(T3)各时点的视觉模拟评分(VAS)。结果:两组检查前、中、后MAP、HR、SpO2比较,操作时间、清醒时间的差异均无统计学意义(P>0.05)。B组术中体动反应较A组明显,差异有统计学意义(P<0.05),A、B组术中呼吸抑制次数的差异无统计学意义(P>0.05)。A组患者术毕清醒后1min(T0)、5min(T1)、10min(T2)、20min(T3)各时点的视觉模拟评分(VAS)较B组低,差异有统计学意义(P<0.05)。结论:地佐辛复合丙泊酚的麻醉镇痛在双气囊小肠镜检查中的应用是安全和有效的。

Clinical Research of Dezocine and Propofol Combination Intravenous Injection for Double-balloon Enteroscopy

Objective:To observe the clinical safety and effect of anaesthetic drugs propofol combined with dezocine in double-balloon enteroscopy examination.Methods:60patients,September 2010to December 2012of our Hospital ASA ⅠorⅡ,scheduled for double-balloon enteroscopy examination were randomly divided into two groups(A,B),n=30 each.Group A received dezocine(0.1mg/kg)intravenous injection,group B received normal saline 5ml intravenous injection before induction.Then two groups received propofol intravenous injection(0.8mg/kg),and two groups both received propofol intravenous pumprate=3～5mg/(kg.h)]for maintaining narcotism.Group A and group B didn’t receive any drug at the end of the examination.The blood pressure(MAP),heart rate(HR)and blood oxygen saturation(SpO2)of two groups were monitored during the examination.The reaction of examination,completion time,recovery time and the total dose of propofol were recorded.Pain score(VAS)were recorded at 1min(T0),5min(T1),10min(T2),20min(T3)after the examination.Results:There had no statistical significance in the perioperative MAP,HR,SPO2,completion time and recovery time of two groups(P>0.05).The body movements of group B were more than group A(P<0.05).There had no statistical significance in the respiratory depression times of group A and B(P> 0.05).Pain score(VAS)at 1min(T0),5min(T1),10min(T2),20min(T3)after the examination of group A was lower than group B(P<0.05).Conclusion:Propofol combined with dezocine can provide a safe and effective means in doubleballoon enteroscopy examination.