| 致死剂量照射的大鼠骨髓移植中输血和环磷酰胺对疗效的影响 |
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| 引用本文： | 阎永堂,冉新泽,魏书庆. 致死剂量照射的大鼠骨髓移植中输血和环磷酰胺对疗效的影响[J]. 中国输血杂志, 1988, 0(4) |
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| 作者姓名： | 阎永堂 冉新泽 魏书庆 |
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| 作者单位： | 第三军医大学，第三军医大学，第三军医大学 |
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| 摘 要： | 本文以γ射线致死剂量照射大鼠研究了骨髓移植(BMT)中输血和环磷酰胺(CY)对疗效的影响.照射后60天各实验组的结果如下:仅用BMT组的活存率为55%,BMT前5天和后1天输血的两组活存率分别为0%和30%.BMT前1天输血组活存率提高到90%,而再用CY时则明显降低疗效.活存>10天和100天者均显示供体型细胞.结果表明,输血提高BMT对致死剂量照射的疗效与输血时间有关,而加用CY则降低疗效.
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Effects of Blood Transfusion and Cyclophosphamide on the Bone Marrow Transplantation in Rats with Lethal γ-irradiation |
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| Abstract: | Therapeutic effects of blood transfusion and cyclophosphamide (CY) on the bone marrow transplantation (BMT) in rats with lethal γ-irradiation were studied. The results of 60-day after irradiation in each experimental group were as follows: The survival rates in the group only treated with BMT were 55%. In the groups with blood transfusion five days before and one day after BMT, the survival rates were 0% and 30% respectively. The survival rates of the group with blood transfusion one day before BMT increased to 90%, but when administration of CY was added the therapeutic effect decreased markedly. The cells of the donor type in the rats survived more than 10 and 100 days. The results showed that the therapeutic effect of BMT in the lethal irradiation was strongly related to the time of blood transfusion, and the additional administration of CY decreased the therapeutic effect. |
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