THE SOLID-PHASE SYNTHESIS OF α-MELANOTROPIN HYDRAZIDE

The solid-phase synthesis of α-melanotropin hydrazide, a new analog of α-MSH, is described. Cleavage of the partially protected peptide from the solid support was accomplished with hydrazine in dimethylformamide. The protecting groups were removed with sodium in liquid ammonia and the product was purified by chromatography on carboxymethylcellulose to give a highly purified and melanotropically active tridecapeptide.