| CD45RA和CD45RO在寻常型银屑病皮损中的表达的研究 |
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| 引用本文： | 张东生,王飞,王刚,杨亚萍,张莉.CD45RA和CD45RO在寻常型银屑病皮损中的表达的研究[J].沈阳医学院学报,2009,11(3):156-158. |
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| 作者姓名： | 张东生 王飞 王刚 杨亚萍 张莉 |
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| 作者单位： | 青海大学附属医院皮肤科,青海,西宁,810001 |
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| 摘 要： | 目的：观察寻常型银屑病患者皮损中CD45RA和CD45RO的表达情况，探讨寻常型银屑病的发病机制。方法：免疫组化检测30例寻常型银屑病患者皮损中CD45RA和CD45RO的表达，取10例正常人的躯干皮肤做正常对照。结果：寻常型银屑病患者皮损中CD45RO的表达明显高于对照组（P〈0．01），CD45RA的表达和对照组比较无统计学意义（P〉0．05）。结论：寻常型银屑病患者皮损真皮中浸润的淋巴细胞以记忆性T淋巴细胞为主，推测细胞免疫在寻常型银屑病的发病中起重要作用。
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| 关 键 词： | 寻常型银屑病 CD45RA CD45RO |
Studying on Expression of CD45RA and CD45RO in the psoriasis vulgaris skin lesion |
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| ZHANG Dong-sheng,WANG Fei,WANG Gang,YANG Ya-ping,ZHANG Li.Studying on Expression of CD45RA and CD45RO in the psoriasis vulgaris skin lesion[J].Journal of Shenyang Medical College,2009,11(3):156-158. |
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| Authors: | ZHANG Dong-sheng WANG Fei WANG Gang YANG Ya-ping ZHANG Li |
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| Institution: | ( Department of Dermatology, Qinghai University Affiliated Hospital, Xining 810001, China) |
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| Abstract: | Objective： To investigate the expression of CD45RA and CIM5RO in the lesions of psoriasis vulgaris. Methods： The expression of CD45RA and CD45RO in the lesions of 30 psoriasis vulgaris were detected with immunohistochemical method and 10 cases of healthy skin were as control. Results： The expression of CIM5RO in psoriasis vulgaris lesion was higher than that in healthy skin, but in CIM5RA there was no statistic difference between the psoriasis vulgaris lesions and controls, Conclusion： The lymphocytesin psoriasis dermis are mainly memory lymphocytes. The cellular immunity plays a main role in the disease. |
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| Keywords: | CD45RA CD45RO |
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