| 99Tcm-MIBI显像对肿瘤多药耐药检测的应用 |
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| 引用本文： | 钱习军.99Tcm-MIBI显像对肿瘤多药耐药检测的应用[J].国际放射医学核医学杂志,2002,26(4):173-176. |
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| 作者姓名： | 钱习军 |
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| 作者单位： | 东南大学医学院血液肿瘤科 |
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| 摘 要： | MDR(多药耐药)是目前肿瘤化疗失败的主要原因,对MDR的检测可以帮助化疗决策的制定,从而使肿瘤患者得到更有效的治疗。99Tcm-MIBI(99Tcm-甲氧基异丁基异腈)是mdr1基因编码的P-gp(P-糖蛋白)和MRP(多药耐药相关蛋白)的转运底物,肿瘤细胞内99Tcm-MIBI摄取减低表明其P-gp的高表达,并与MRP的表达相关。因此,99Tcm-MIBI显像可在治疗前预测对化疗的反应,并为选择更有效的化疗策略提供依据。99m
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| 关 键 词： | 多药耐药 99Tcm-甲氧基异丁基异腈 P-糖蛋白 多药耐药相关蛋白 肿瘤 |
| 文章编号： | 1001-098X(2002)04-0173-04 |
| 修稿时间： | 2002年4月24日 |
The application of 99Tcm-MIBI imaging to detect multidrug resistance |
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| QIAN Xi-jun.The application of 99Tcm-MIBI imaging to detect multidrug resistance[J].International Journal of Radiation Medicine and Nuclear Medicine,2002,26(4):173-176. |
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| Authors: | QIAN Xi-jun |
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| Abstract: | Multidrug resistance is the main cause of chemotherapy failure,To detect multidrug resistance is helpful to develop chemotherapy regimens and more effective treatment of patients with tumors. 99 Tc m -sestamibi is a transport sub-strate of mdr1-encoded P-glycoprotein and MRP.The lower 99 Tc m -sestamibi accumulation indicates the higher expression of P-glycoprotein in tumor cells.Tt is also related to the expression of MRP.As a result,response to chemotherapy can be estimated before starting treatment by means of 99 Tc m -sestamibi imaging and more effective protocol can be chosen. |
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| Keywords: | multidrug resistance 99 Tc m -sestamibi P-glycoprotein multidrug resistance related protein tumor |
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