老年原发性非小细胞性肺癌临床特征

[目的]明确老年原发性非小细胞性肺癌临床及肿瘤生物学特征,为其早期诊断和治疗提供理论指导。[方法]分析安徽医科大学第一附属医院1996年至1998年3年间经病理或(和)细胞学确诊的原发性非小细胞性肺癌病例,将其中大于70岁(老年组)和小于40岁(青年组)作为研究对象,按照临床症状、组织学类型、临床分期、治疗方式和生存率等跟踪随访3年并将相关资料进行统计分析。[结果]在3年间确诊为原发性非小细胞性肺癌病例中,老年组148例,青年组104例。老年组以男性为主,青年组以女性为主,差异分别具有显著性(P<0.05);老年组鳞癌多见,青年组腺癌多见,差异分别具有显著性(P<0.05);老年组多采用以支持和化疗为主的综合治疗,青年组采用以手术为主的综合治疗方案;老年组3年累计生存率为17.5%,中位生存数为14个月;青年组3年累计生存率是28.6%,其中位生存数为18.2个月,差异具有显著性(P=0.018)。[结论]老年原发性非小细胞性肺癌患者主要是男性和鳞癌;老年组的总的生存率和预后较青年组差。

The Clinical Characteristics in Elderly Patients with Non-small Cell Lung Cancer

To investigate the clinical and biological characteristics in elderly patients with non-small cell lung cancer(NSCLC)and provide the theory measures for the early diagnosis and treatment for the elderly patients.Patients with NSCLC,cytologically and/or pathologically proved from1996through1998in the first affiliated hospital of Anhui medical university was enrolled this study.Among them,148pa-tients were>70years old and104patients<40years old.The symptoms,the clinicopathologic characteristics,treatment modalities,histology,staging,treatment modality,and survival rates were analyzed Pearson's test and the Kaplan-Meier method with a log-rank test were used for statistical analysis.We found significantly more male patients(P<0.05)and squamous cell carcinoma(P<0.05)in the elderly patients when compared with the younger patients who had more female and adenocarcinoma.Cough was the most frequent presenting symp-tom in both age groups,followed by dyspnea,chest pain,and hemoptysis.The elderly patients received the com-prehensive treatment with non-surgical intervention plus supportive care more frequently than the younger pa-tients who received surgical intervention more frequently than the aged(P<0.05).Accumulative overall survival rate analysis for three years was17.5%,in the elderly patients and28.6%in the younger patients.Median sur-vival was14and18.2months respectively(P<0.01).[Conclusions]The male and squamous cell carcinoma are predominant in the elderly NSCLC with patients when compared those in the younger patients.The prognosis in the elderly patients is worse than that in younger patients.