局部静电疗法治疗银屑病临床疗效及机理研究

目的　探讨局部静电疗法治疗静止期斑块型银屑病的临床疗效和机理。方法　应用局部静电疗法对 2 7例静止期斑块型银屑病患者进行临床疗效观察 ,并与外用激素疗法作自身对照 ;运用免疫组化SP法及计算机图像分析法检测部分患者表皮中热休克蛋白HSP2 7和HSP70 的表达情况。结果　局部静电疗法总有效率 77.78% ,经Ridit检验 ,与外用激素疗法相比疗效无显著性差异 (u =0 .5 93 1,P >0 .0 5 ) ;患者皮损处表皮细胞中HSP2 7和HSP70 表达缺失 ,疗后恢复表达。结论　局部静电疗法是治疗静止期斑块型银屑病有效而安全的方法 ,其机理可能为诱导表皮热休克蛋白的表达 ,调节细胞的增生和分化 ,发挥其应激保护作用。

Clinical Effects and Mechanism Research of the Topical Application of Electrostatics in the Treatment for Static Plaque Psoriasis

Objective To investigate the clinical effects and the mechanism of the topical application of electrostatics(TAE) in the treatment of static plaque psoriasis.Methods TAE was used to treat 27 cases with static plaque psoriasis,compared with topical application of corticosteroids(TAC),immunohistochemical SP method and image analysis were used to measure the expression of HSPs in epidermis.Results The total effective rate of TAE was 77.78%,no significant difference with that of TAC( P >0.05),and the amounts of the HSPs in epidermis of psoriasis returned to normal after treatment.Conclusion TAE is an effective and safe method to cure static plaque psoriasis,and the stress protection of the HSPs may play an important role in the mechanism of TAE.