树突状细胞对自然杀伤细胞功能调控的研究进展

树突状细胞（DC）和自然杀伤细胞（NK）分别在固有免疫和适应性免疫中发挥着关键作用,二者之间还存在着复杂的交互作用.就DC对NK细胞功能的影响而言,前者可以通过膜表面分子直接激活静息的NK细胞,也可以在趋化因子的作用下将NK细胞招募至炎症部位或次级淋巴结,通过分泌可溶性细胞因子促进NK细胞活化、增殖,增强产生IFN-γ的能力,提高细胞毒活性,进而增强其抗病毒、抗肿瘤等效应.DC对NK细胞功能调控的研究在感染、肿瘤和免疫排斥等的防治中具有重要意义.

Recent advances in dendritic cell-mediated regulation of natural killer cell function

Dendritic cells (DCs) play key roles in adaptive immunity, while natural killer (NK) cells play vital roles in innate immunity. There is a complicated cross-talk between these two types of immune cells.DCs can directly trigger the activation of resting NK cells by membrane-associated molecules and recruit of NK cells to inflammatory sites or secondary lymphoid organs by secreting chemokines. DCs can also promote the activation and proliferation of NK cells by producing soluble cytokines and increase NK's capability do secrete IFN-γ. As a result, the cytotoxicity and the anti-virus as well as and anti-tumor abilities of NK cells enhanced.DC-mediated regulation of NK cells functions might have great potential in the prevention and treatment of infection, tumor and immune rejection.