| 谷氨酰胺对梗阻性黄疸大鼠可溶性白细胞介素2受体的影响 |
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| 引用本文： | 韩刚,陈云波,张弘. 谷氨酰胺对梗阻性黄疸大鼠可溶性白细胞介素2受体的影响[J]. 中国实验诊断学, 2005, 9(6): 934-935 |
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| 作者姓名： | 韩刚 陈云波 张弘 |
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| 作者单位： | 吉林大学第二临床医院,基本外科,吉林,长春,130041 |
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| 基金项目： | 吉林省科技厅资助项目（20030542-2） |
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| 摘 要： | 目的探讨免疫营养剂谷氨酰胺(Glutamine,Gln)对梗阻性黄疸大鼠可溶性白细胞介素2受体(sIL-2R)的影响。方法90只大鼠随机分成对照组(C组)、梗阻性黄疸组(J组)和谷氨酰胺干预组(G组)各30只,于术后5周抽尽腔静脉血测定血清sIL-2R。结果J组与G组sIL-2R水平较C组明显升高(P<0·01),G组sIL-2R水平较J组明显降低,差异显著(P<0·01)。结论谷氨酰胺能够降低梗阻性黄疸大鼠sIL-2R水平,改善机体免疫状态。
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| 关 键 词： | 梗阻性黄疸 谷氨酰胺 白细胞介素2受体 |
| 文章编号： | 1007-4287(2005)06-0934-03 |
| 收稿时间： | 2004-08-29 |
| 修稿时间： | 2004-08-29 |
The effect of glutamine on soluble interleukin 2 receptor of obstructive jaundice rat |
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| HAN Gang,CHEN Yun-bo,ZHANG Hong. The effect of glutamine on soluble interleukin 2 receptor of obstructive jaundice rat[J]. Chinese Journal of Laboratory Diagnosis, 2005, 9(6): 934-935 |
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| Authors: | HAN Gang CHEN Yun-bo ZHANG Hong |
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| Affiliation: | Department of General Surgery, the Second Hospital of Jilin University, Changchun 130041, China |
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| Abstract: | Objective To investigate the effect of glutamine(Gln) on soluble interleukin 2 receptor(sIL-2R) of obstructive jaundice(OJ) rats. Methods 90 rats were divided into contrast group(C group), obstructive jaundice group(J group) and Gln treatment group(G group). All the venacavalblood samples were obtained 5 weeks after operation, and then detect the serum sIL-2R level. Results The serum sIL-2R level of J and G group was obviously higher than that of C group(P<0.01), and the serum sIL-2R level of G group lower than the J group. And the difference between Jgroup and G group was significant(P<0.01). Conclusion The administration of glutamine can lower the serum sIL-2R level of OJ rats, thus can improve the immune status. |
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| Keywords: | obstructive jaundice glutamine soluble interleukin 2 receptor |
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