Antiprotozoal activity of Neurolaena lobata. |
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| Authors: | I Berger C M Passreiter A Cáceres W Kubelka |
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| Institution: | Institut für Pharmakognosie, Universit?t Wien, Pharmaziezentrum, Althanstrabetae 14, A-1090 Wien, Austria. |
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| Abstract: | Extracts, fractions and sesquiterpene lactones from Neurolaena lobata (L.) R. Br. (Asteraceae), a traditional medicinal plant from Guatemala, were tested in vitro against Leishmania spp. promastigotes, Trypanosoma cruzi trypomastigotes and epimastigotes and Trichomonas vaginalis trophozoites. The ethanol extract inhibited the parasite growth of L. mexicana, T. cruzi and T. vaginalis significantly. The pure germacranolides 1 and a mixture of 2 and 3, isolated from the ethonal extract, were highly active against L. mexicana and T. cruzi. |
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| Keywords: | Neurolaena lobata (L ) R Br Leishmania spp Trypanosoma cruzi Trichomonas vaginalis sesquiterpene lactones neurolenins |
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