| 肝细胞微环境：抗肝纤维化药物的新靶点 |
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| 引用本文： | 刘庆山,张梓倩,崔箭,田燕泽,庞宗然. 肝细胞微环境：抗肝纤维化药物的新靶点[J]. 国外医学(药学分册), 2010, 0(1): 21-23,59 |
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| 作者姓名： | 刘庆山 张梓倩 崔箭 田燕泽 庞宗然 |
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| 作者单位： | 中央民族大学中国少数民族传统医学研究院; |
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| 基金项目： | 国家自然科学基金资助项目(30973959,30873249) |
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| 摘 要： | 本文以肝星状细胞为切入点,分析了肝细胞微环境与肝纤维化的关系。肝细胞微环境由肝星状细胞、细胞外基质、基质金属蛋白酶、枯否细胞、自然杀伤细胞等共同构成,而肝纤维化是由其相互作用的失衡所致。因此提出,应将肝细胞微环境作为治疗肝纤维化的复合靶点并应用于传统民族药物筛选,以充分发挥民族药物多机制、多靶点的优势,研制抗肝纤维化的创新药物。
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| 关 键 词： | 肝纤维化 微环境 肝星状细胞 药物靶点 |
Hepatic cellular microenvironment:a novel drug target for anti-hepatic fibrosis |
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| LIU Qing-shan,ZHANG Zi-qian,CUI Jian,TIAN Yan-ze,PANG Zong-ran. Hepatic cellular microenvironment:a novel drug target for anti-hepatic fibrosis[J]. Foreign Medical Sciences(Section of Pharmarcy), 2010, 0(1): 21-23,59 |
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| Authors: | LIU Qing-shan ZHANG Zi-qian CUI Jian TIAN Yan-ze PANG Zong-ran |
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| Affiliation: | China Minority Traditional Medicine Center;Minzu University of China;Beijing 100081;China |
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| Abstract: | To screen anti-hepatic fibrosis drugs,the relationship between hepatocellular microenvironment and hepatic fibrosis is analyzed and focused on hepatic stellate cells in this paper.Hepatocellular microenvironment is composed of hepatic stellate cells,extracellular matrix,matrix metalloproteinases,Kupffer cells and natural killer cells.Hepatic fibrosis is induced by the imbalance among the parts of hepatocellular microenvironment.So hepatocellular microenvironment should be a complex drug target for the treat... |
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| Keywords: | hepatic fibrosis microenvironment hepatic stellate cells drug targets |
| 本文献已被 CNKI 维普 等数据库收录！ |
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