鹿角方对慢性心力衰竭患者左室重构的干预作用

目的探讨鹿角方对慢性充血性心力衰竭(CHF)患者左室重构的干预作用。方法将120例CHF患者随机分为鹿角方组、地高辛组和开搏通组,各40例,并给予相应的治疗,疗程3个月。观察临床总有效率、肾虚症状积分、心胸比例、射血分数(EF)、心输出量(CO)、室间隔厚度(IVST)、左室后壁厚度(PWT)、左室重量指数(LVMI)和血浆内皮素(ET)、血管紧张素II(AngII)、心钠素(ANP)水平等的改变。结果鹿角方组的临床总有效率为82.5%,能显著提高EF和CO(P<0.05),降低IVST、PWT和LVMI(P<0.01),下调血浆ET、AngII和ANP水平(P<0.01),其疗效与卡托普利相当,并能显著改善肾虚症状,而地高辛或卡托普利组却未呈现该方面作用。结论鹿角方能加强心脏收缩功能、改善血流动力学,干预心室重构,从而延缓心力衰竭的进程。

Intervention Effect of "Lujiao Decoction" on Left Ventricular Remodeling in Patients with Congestive Heart Failure

Objective To evaluate the intervention effect of "Lujiao Decoction" on left ventricular remodeling in patients with congestive heart failure(CHF).Methods 120 cases of CHF were randomly divided into Lujiao decoction group,digoxin group and captopril group.The total clinical effective rate,integra of the symptoms of renal asthenia,and ejection fraction(EF),cardiac output(CO),interventricular septal thickness(IVST),posterior wall thickness(PWT),left ventricular mass index(LVMI)of echocowdio-gram as well as the measurement of plasma endothelin,angiotensin II and atrial natriuretic peptide were observed in three groups.Results The total clinical effective rate of Lujiao decoction group was 82.5%,EF and CO were significantly improved(P < 0.05),IVST,PWT and LVMI were also reduced significantly(P < 0.01),the level of plasma ET,Ang II and ANP was totally decreased significantly(P < 0.01).Its efficacy acted as well as that of captopril.The integra of the symptoms of renal asthenia was also decreased significantly(P < 0.01),however no significant difference in the captopril or digoxin group.Conclusion The Lujiao decoction is effective in enhencing cardiac contraction,improving hemodynamics preventing left ventricular from remodeling,so that it could postpone the processes of CHF.