Sexual dimorphism in the regulation of caloric intake and body weight of rats fed different diets |
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| Authors: | J K Young D M Nance R A Gorski |
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| Affiliation: | 1. Department of Anatomy and Brain Research Institute, University of California, Los Angeles, CA 90024 USA;2. Department of Anatomy, College of Medicine, University of South Florida, Tampa, FL 33612 USA |
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| Abstract: | Female, androgenized female (AF), and male rats were given access to 1 of 3 diets—chow (C), high-dextrose (D-chow:dextrose, 2:1), and high-fat (F-chow:Crisco, 2:1) for 2 months. Caloric intake (CI), water intake, and body weights were monitored daily. Responses to gonadectomy and a single injection of estradiol benzoate (EB) were also studied. For females, F- and C-fed rats had comparable CI's, whereas D-fed rats chronically ate much less. For males, F-fed rats overate, whereas C- and D-fed rats had comparable CI's. The pattern of CI of AF rats fed the 3 diets was intermediate between that of males and females. Male rats were less responsive to the anorexic effects of EB than were the other two groups, and the F-diet potentiated the anorexic effects of EB in all three groups. Results are discussed in terms of a sex difference in the hypothalamic regulation of feeding behavior which is modulated by gonadal hormones. |
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| Keywords: | Sex Differences Food intake Body weight Dietary alterations |
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