急性脑梗死病人红细胞膜唾液酸含量与红细胞免疫功能的检测

①目的　探讨红细胞膜唾液酸 (RBCm SA)含量及红细胞免疫功能 (RBCIF)与急性脑梗死 (ACI)的关系。②方法　检测了 19例ACI病人RBCm SA、血浆唾液酸 (P SA)、循环免疫复合物 (CIC)的含量及RBCIF ,并与2 8例正常人进行比较。③结果　ACI病人RBCm SA和RBCIF低于正常人 (t=- 2 .5 12 ,P <0 .0 5 ;t=- 3.12 1,P<0 .0 1) ,而P SA和CIC高于正常人 (t=2 .875 ,P <0 .0 1;t=2 .4 0 3,P <0 .0 5 )。不论正常人还是病人 ,RBCm SA与RBCIF呈正相关 (r =0 .4 97,P <0 .0 1;r =0 .4 83,P <0 .0 5 ) ,RBCm SA与P SA呈负相关 (r =- 0 .4 6 6、- 0 .5 0 6 ,P <0 .0 5 )。④结论　ACI病人红细胞免疫功能降低与RBCm SA代谢异常相关。

DETECTION OF ERYTHROCYTE MEMBRANE SIALIC ACID AND ERYTHROCYTE IMMUNE FUNCTION IN PATIENTS WITH ACUTE CEREBRAL INFARCTION

Objective To evaluate the relationship between acute cerebral infarction(ACI) and red blood cell membrane sialic acid(RBCm SA) as well as red blood cell immune functions(RBCIF). \ Methods\ RBCm SA, plasma sialic acid(P SA), RBCIF and circulating immune complexes(CIC)in 19 patients with ACI were detected, and compared with 28 normal controls. \ Results\ RBCm SA and RBCIF in the patients were significantly lower than those in the controls ( t=-2.512,P<0.05;t=-3.121,P <0.01), and P SA and CIC in the patients were significantly higher in comparison with the controls ( t=2.875,P<0.01;t= 2.403 ,P <0.05). Positive correlation was found between RBCm SA and RBCIF ( r=0.497,P<0.01;r=0.483,P <0.05), and negative one was showed between RBCm SA and P SA ( r=-0.466,-0.506,P <0.05). \ Conclusion\ The decrease of RBC immune function in patients with ACI is related to the metabolism disorder of RBCm SA.