迈之灵治疗视网膜静脉阻塞

目的:观察迈之灵治疗视网膜静脉阻塞的疗效和安全性。方法:41例(41眼)临床诊断为视网膜静脉阻塞病人被随机分为2组,迈之灵组23例(23眼),予迈之灵2片,po,bid,4wk为一疗程,连续3个疗程。丹参组18例(18眼),先予丹香冠心注射液16mL加入5%葡萄糖注射液(或氯化钠注射液)500mL中,静脉滴注,qd,1wk后改为丹参片,3片,po,tid,连续服用11wk。观察治疗前后视力、视野及视网膜电流图的动态变化,并评定疗效。结果:治疗wk4,8末,迈之灵组视力提高优于丹参组(P<0.05,P<0.01)。治疗wk4末,迈之灵组渗出、出血吸收率61%,高于丹参组的28%(P<0.05);视网膜血管渗漏改善明显,优于丹参组(P<0.05)。治疗wk12末,迈之灵组暗适应眼最大电反应的b波振幅及b/a值与治疗前相比明显提高(P<0.01),且2组有差异(P<0.05,P<0.01);迈之灵组总有效率91%,丹参组56%,2组疗效有显著差异(P<0.05),均未见不良反应。结论:迈之灵治疗视网膜静脉阻塞有效、安全,早期疗效优于丹参。

Clinical therapy of retinal vein occlusion with aescuven forte

AIM:To investigate the therapeutic effect and safety of aescuven forte on retinal vein occlusion (RVO). METHODS: Forty-one patients (41 eyes) with RVO were divided into two groups randomly: 23 patients (23 eyes) in aescuven forte group receiving aescuven forte, 2 tablets, po, tid, 4 wk as a course altogether for 12 wk,and 18 patients (18 eyes) in Salvia miltiorrhiza group receiving Danxiang Guanxin injection 16 mL 5 % glucose injection (or sodium chloride injection) 500 mL, iv, gtt, qd for 1 wk followed by Salvia miltiorrhiza tablets, 3 tablets, po, tid, for 11wk. The visual activity, visual field and electroretinogram were observed before and 4, 8, 12 wk after the treatment. RESULTS: At the end of 4, 8 wk after treatment, the improvement of visual activity in aescuven forte group was much better than that in Salvia miltiorrhiza group with statistical difference between two groups (P<0.05,P<0.01). At the end of 4 wk after treatment, the absorbency of bleeding and exudation of aescuven forte group was 61 %, higher than that of Salvia miltiorrhiza group (28 %, P< 0.05). The maximum electroneflex amplitude of dark adaptation eye b wave and b/a in aescuven forte group were meliorated 12 wk later(P<0.01)showing more improvement than those in Salvia miltiorrhiza group (P<0.05,P<0.01). The total effective rates were 91 % and 56 % in aescuven forte and Salvia miltiorrhiza group respectively. There was a significant statistical difference in clinic efficacies between the two groups (P<0.05). No obvious adverse reactions occurred in both groups. CONCLUSION: Aescuven forte is efficient and safe in the treatment of RVO and especially superior to Salvia miltiorrhiza in the early phase of the treatment.