| 川芎嗪对博莱霉素致肺间质纤维化大鼠MMP-2表达的影响 |
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| 引用本文： | 王增欣,孙晓芳,李少春,崔娜,段斐. 川芎嗪对博莱霉素致肺间质纤维化大鼠MMP-2表达的影响[J]. 河北职工医学院学报, 2010, 27(4): 19-20,29 |
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| 作者姓名： | 王增欣 孙晓芳 李少春 崔娜 段斐 |
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| 作者单位： | 1. 河北省保定市第五医院,河北,保定,071000
2. 河北大学,河北,保定,071000 |
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| 基金项目： | 河北省科技攻关课题，河北省保定市科技局资助课题 |
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| 摘 要： | 目的研究川芎嗪对博莱霉素致肺间质纤维化大鼠MMP-2表达的影响。方法选SD雄性大鼠40只,随机分为4组即正常组、模型组、阳性药物对照组及川芎嗪组,每组10只。于28 d麻醉后取肺组织,进行HE、Mallary染色,并进行MMP-2的免疫组化染色。结果模型组MMP-2表达上调,川芎嗪组表达降低,表明川芎嗪可以降低博莱霉素所致肺纤维化大鼠MMP-2的表达。结论川芎嗪可能通过降低MMP-2表达发挥抗纤维化的作用。
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| 关 键 词： | 川芎嗪 肺间质纤维化 MMP-2 |
TMP on the expression of MMP-2 and bleomycin-induced pulmonary fibrosis in rats |
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| Affiliation: | Wang Zengxin, Sun Xiaofang, Li Shaochun, et al ( 1. The Fifth Hospital of Baoding City, Baoding 071000, China; 2. Hebei University, Baoding 071000, China) |
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| Abstract: | Objective To study the TMP on the expression of MMP-2 fibrosis in rats. Methods 40 SD male rats were randomly divided into and bleomycin-induced pulmonary sham operation group, model group, positive control group and TMP group, a total of 4 groups of 10 each. 28 days after anesthesia in lung tissues were harvested for HE, Mallary staining and MMP-2 immunohistochemical staining. Results MMP-2 upregulation in the untreated group, TMP group was decreased, indicating that TMP can reduce bleomycin- induced pulmonary fibrosis in rats the expression of MMP-2. Conclusion TMP can decrease the expression of MMP-2 play a role in anti-fibrosis. |
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| Keywords: | MMP-2 |
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