国产左旋布比卡因腰-硬联合麻醉用于全子宫切除术效果观察

目的:评价国产左旋布比卡因腰-硬联合麻醉(CSEA)用于全子宫切除术的有效性及安全性。方法:选择CSEA全子宫切除术100例,随机分为进口罗哌卡因组和国产左旋布比卡因组,每组50例。进口罗哌卡因组蛛网膜下腔用0.75%罗哌卡因2 m l,国产左旋布比卡因组蛛网膜下腔用0.75%左旋布比卡因2 m l。采用针刺法评估感觉阻滞效果,记录起效、维持时间和最高阻滞平面;采用改良B rom age评分评估运动阻滞效果,记录起效时间和维持时间;评估术中麻醉质量与肌松效果及不良反应的发生情况。结果:2组感觉阻滞起效、维持、运动阻滞起效和维持时间差异无统计学意义(P>0.05),平均动脉压维持平稳;除手术开始和术毕时2组血氧饱和度有差异外,余麻醉后不同时点的心率、脉搏血氧饱和度差异无统计学意义(P>0.05);2组肌松效果较好,不良反应发生率低,且差异无统计学意义。结论:国产左旋布比卡因用于CSEA全子宫切除术患者麻醉效果满意,无明显不良反应。

Anesthetic efficacy and safety of levobupivacaine for hysterectomy under combined spinal-epidural anesthesia

Objective：To assess the efficacy and safety of demostic product levobupivacaine for hysterectomy under combined spinal-epidural anesthesia（CSEA）.Methods：One hundred patients ASA gradeⅠorⅡundergoing elective hysterectomy under CSEA were randomly divided into 2 groups（n=50 each）：levobupivacaine and ropivacaine.Each group was received intrathecal 0.75% levobupivacaine or ropivacaine injection 2 ml.The onset time and duration of sensory and motor block,the block height,degree of abdominal muscle relaxation,anesthetic efficacy and side effects were recorded.Results：There was no significant difference in the onset time,duration and degree of sensory and motor block among the 2 groups（P0.05）.There was no significant difference including mean arterial blood pressure and the degree of abdominal muscle relaxation and anesthetic efficacy and side effects.While vital signs of heart rate and arterial oxygen saturation had significant differences after anesthesia（P0.01）.Conclusions：The demostic product levobupivacaine for hysterectomy has satisfactory anesthetic effects compared with ropivacaine under CSEA and has no significant side effects.