超微粉碎对罗勒显微特征及总黄酮体外溶出的影响简

目的：对罗勒超微粉和常规粉中总黄酮的体外溶出、显微特征及粉体学性质进行考察.方法：采用比色法测定罗勒超微粉和常规粉中总黄酮体外溶出量和溶出速率,用生物显微镜进行显微特征观察,测定粉体休止角和堆密度.结果：罗勒超微粉和常规粉中总黄酮体外溶出量无显著性差异,超微粉体的溶出速率较常规粉体明显增加.罗勒超微粉颗粒均匀,基本无完整细胞存在.与常规粉相比,罗勒超微粉的休止角增大,堆密度减小.结论：超微粉碎不会影响总黄酮的体外溶出量,但可明显提高其溶出速率.植物细胞破壁率明显提高,但流动性和充填性变差,有待于在制剂生产中进行改进.

Effects of ultramicro pulverization on the microscopic characteristics of Ocimum bacilicum and on the in vitro dissolution of total flavone

Objective： To investigate the in vitro dissolution of total flavone, the microscopic characteristics of Ocimurn bacilicurn and the nature of the ultramicro and traditional powder forms of Ocimurn bacilicum. Methods： Chromatometry was used to detect the in vitro dissolution amount and dissolution rate of total flavone in the ultramicro and traditional powder forms of Ocirnurn baciLicurn. Microscopic characteristics of Ocimum bacilicum was observed by biological microscopy, and the angle of repose and the bulk density were also measured. Results： There were no statistically significant differences in the dissolution amounts of the 2 powder forms of Ocimum bacilicurn, but the dissolution rate of the ultramicro powder increased obviously, as compared with that of the traditional powder. The ultramicro powder particles were more uniform in shape and almost no intact cells could be observed. When compared with those of the traditional powder, the angle of repose increased, while the bulk density decreased. Conclusion： Ultramicro pulverization would affect the in vitro dissolution of total flavone, but it could significantly increase its dissolution rate. The rate of plant cell wall disruption increased significantly, but its mobility and filling ca pacity became weaker, which required further improvement in the production of preparations.