0. 02% 氟米龙联合玻璃酸钠治疗中度干眼的临床研究

目的观察0．02％氟米龙滴眼液联合玻璃酸钠滴眼液治疗中度干眼的临床疗效。方法将2012年6月-2012年10月在复旦大学附属眼耳鼻喉科医院眼科门诊诊断为中度干眼的41例（41眼）患者随机分成A、B2组，A组给予0．02％氟米龙联合玻璃酸钠滴眼液，B组单独应用玻璃酸钠滴眼液，观察2组患者在用药前、治疗14d后及治疗28d后的眼表疾病指数OSDI评分、结膜充血评分、角膜荧光素染色评分、泪膜破裂时间（BUT）、基础泪液分泌试验（SIt）及睑板腺分泌物评分。结果用药28d后，A组和B组干眼患者在OSDI评分、结膜充血评分、角膜荧光素染色评分、BUT、SIt及睑板腺分泌物评分上均有明显改善（P〈0．05）；A组比B组更有助于结膜充血评分及睑板腺分泌物评分的改善（P〈0．05）。结论氟米龙联合玻璃酸钠滴眼液能减轻眼表的炎性充血，改善睑板腺功能。

Therapeutic effect of 0.02 % fluorometholone combined with sodium hyaluronate on patients with moderate dry eye disease

Objective To investigate the clinical effect of 0. 02% fluorometholone combined with sodium hyaluronate in the treatment of patients with moderate dry eye disease. Methods Forty-one patients （41 eyes ） diagnosed as moderate dry eye disease in Shanghai EENT Hospital from June 2012 to October 2012 were divided into 2 groups randomly. The patients of group A were treated with 0.02% fluorometholone eye drops combined with sodium hyaluronate eye drops, and the patients of group B were treated with sodium hyaluronate eye drops only. All the patients were evaluated with OSDI scores, conjunctival hyperemia scores, corneal fluorescein staining scores, break-up time （ BUT）, Schirmer and meibomian gland secretion scores at three time points： before treatment, 14 days and 28 days after treatment. Results OSDI scores, conjunctival hyperemia scores, corneal fluorescein staining scores, BUT, Schirmer and meibomian gland secretion scores had significant improvements in all patients after 28-day treatment （ P 〈 0.05 ）. Conjunctival hyperemia scores and meibomian gland secretion scores improved significantly in group A than those in group B （P 〈 0.05）. Conclusions Fluorometholone combined with sodium hyaluronate can relieve conjunctival hyperemia and improve meibomian gland function. （Chin J Otohthalmol and Otorhinolarvngol,2014,14：100-103）