| 粘着斑激酶的表达与直肠癌侵袭、转移的相关性研究 |
| |
| 引用本文： | 官国先,寿楠海. 粘着斑激酶的表达与直肠癌侵袭、转移的相关性研究[J]. 山东医药, 2001, 41(12): 7-8 |
| |
| 作者姓名： | 官国先 寿楠海 |
| |
| 作者单位： | 山东大学齐鲁医院 |
| |
| 摘 要： | 应用免疫组化S-P方法检测78例直肠癌手术标本中FAK的表达情况.结果示直肠癌原发灶FAK表达阳性率为79.49%,其中无区域淋巴结转移者阳性率为60.71%,有区域淋巴结转移者阳性率为90%(P＜0.01),FAK表达水平与直肠癌浸润深度和Dukes′分期呈正相关(P＜0.01,P＜0.01).FAK阳性者术后3年、5年生存率分别为44.4%、33.99%.而阴性者为88.24%、82.35%,二组均有显著性意义(P＜0.01,P＜0.01).认为直肠癌由于FAK增加,加速了恶性细胞的增殖、浸润和转移;检测直肠癌组织中FAK表达状况,有助于进一步了解直肠癌生物学行为和预后判断.
|
| 关 键 词： | 直肠癌 FAK 表达水平 阳性率 癌侵袭 区域淋巴结转移 粘着斑激酶 增殖 行为 显著性 |
| 修稿时间： | 2000-03-29 |
Expression of FAK correlation with invasion and metastasis of rectal carcinoma |
| |
| Guan Guoxian,Shou Nanhai. Expression of FAK correlation with invasion and metastasis of rectal carcinoma[J]. Shandong Medical Journal, 2001, 41(12): 7-8 |
| |
| Authors: | Guan Guoxian Shou Nanhai |
| |
| Abstract: | The expression of FAK was examined immunohistochemically in resected rectal carcinoma,using anti monoclonal antibody.The results showed 78 patients tested,79.49% were positive staining of FAK in the primary lesions,while others(20.51%) were negative.Tumors with regional nodal metastasis showed significantly higher positive staining rate than those without nodal involvement.FAK expression is correlated with tumor invasion(P<0.01) or the progression of Dukes stage(P<0.01).Survival rate at 3 and 5 years was 44.4% and 33.99% respectively for positive staining group of FAK,compared to 88.24% and 82.35% respectively for negative staining group(P<0.01).The data indicated that FAK increased proliferation,invasion and metastasis.The expression of FAK may be a useful tool for prognosis of human rectal carcinoma. |
| |
| Keywords: | Rectal neoplasm FAK Immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
