谷红注射液联合丹参多酚酸盐治疗急性脑梗死的临床研究

目的探讨谷红注射液联合丹参多酚酸盐治疗急性脑梗死的临床效果。方法选取2016年5月—2019年5月山东省耳鼻喉医院(山东省立医院西院)收治的脑梗死患者400例,随机分为对照组(200例)和治疗组(200例)。对照组静脉滴注注射用丹参多酚酸盐,200 mg/次加入生理盐水250 mL,1次/d。治疗组在对照组基础上静脉滴注谷红注射液,20 mL/次加入生理盐水250 mL,1次/d。两组患者均治疗2周。观察两组患者临床疗效,同时比较治疗前后两组患者血浆黏度、全血低切黏度、血浆纤维蛋白原、全血高切黏度,以及肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、丙二醇(MDA)、超氧化物歧化酶(SOD)、单个核细胞血红素加氧酶(HO-1)和转录因子红系衍生核因子E2相关因子2(Nrf2)水平。结果治疗后,对照组和治疗组临床有效率分别为86.00%和92.50%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者血浆黏度、全血低切黏度、血浆纤维蛋白原和全血高切黏度均显著低于治疗前(P0.05),且治疗组比对照组更低(P0.05)。治疗后,两组患者TNF-α、IL-6、MDA水平均较治疗前显著降低(P0.05),而SOD、HO-1和Nrf2水平显著高于治疗前(P0.05),且治疗组患者上述指标明显好于对照组(P0.05)。结论谷红注射液联合丹参多酚酸盐治疗脑梗死疗效确切,可明显减轻炎性及氧化应激反应,安全性高。

Clinical study on Guhong Injection combined with salvianolic acid salt in treatment of acute cerebral infarction

Objective To explore the effect of Danhong Injection combined with fondaparinux sodium on immunological indicators and coagulation-fibrinolysis system in patients with pulmonary embolism. Methods Patients (80 cases) with pulmonary embolism in the Second People''s Hospital of Kashgar from August 2014 to August 2018 were selected as the study subjects. Patients were randomly divided into control group and observation group, with 40 patients in each group. Patients in the control group were subcutaneously injected with Fondaparinux Sodium Injection, 2.5 mg/time, once daily, combined with warfarin anticoagulation for 5 days from the 4th day, and the dosage of warfarin was adjusted by monitoring the INR. After that, Fondaparinux Sodium Injection was stopped and warfarin anticoagulation was continued. Patients in the observation group were iv administered with Danhong Injection on the basis of control group, and 20 mL Danhong Injection was added to 250 mL sodium chloride solution, once daily. Both groups were treated continuously for 2 weeks. The clinical efficacy in two groups was observed, and the indexes of immunology and coagulation-fibrinolysis system were compared before and after treatment. Results After treatment, the total effective rate in the observation group was 90.00%, which was significantly higher than 72.50% in the control group (P<0.05).Compared with before treatment, the immunological indexes in two groups were significantly improved (P<0.05), and the indexes in the observation group was better than those in control group (P<0.05). Compared with before treatment, the levels of D-D, FDP, PAI-I, and tPA in two groups were significantly decreased after treatment, and the levels of PT and PLT were significantly increased (P<0.05). Moreover, the indicators of coagulation and fibrinolysis in the observation group were significantly better than those in the control group (P<0.05). Conclusion Danhong Injection combined with fondaparinux sodium can effectively improve the immune function and the coagulation and fibrinolysis system of patients, with a safe and significant effect, and has positive significance in promoting the rehabilitation of patients with pulmonary embolism.