保肺颗粒祛痰、平喘、止咳、抗炎作用的药效学研究

目的:研究保肺颗粒的止咳、平喘、祛痰、抗炎作用。方法:通过小鼠酚红分泌实验观察其祛痰作用、通过磷酸组胺引起豚鼠的哮喘反应,观察其平喘作用、通过SO2引起的小鼠咳嗽反应,观察其止咳作用、通过二甲苯致小鼠耳廓肿法,观察其抗炎作用、通过角叉菜胶致大鼠足趾肿胀法,观察其抗炎作用。结果:对小鼠耳廓肿炎性反应模型的实验表明:保肺颗粒高、中、低剂量均能显著抑制二甲苯引起的小鼠耳肿胀,其肿胀度、肿胀率显著降低。对小鼠的祛痰(气管段酚红法)实验表明:保肺颗粒高、中、低剂量均能增加小鼠酚红排出量。对豚鼠的平喘(喷雾致喘法)实验表明:保肺颗粒高剂量能明显提高磷酸组胺引起的豚鼠哮喘潜伏期延长率,中、低剂量也可提高豚鼠哮喘潜伏期延长率,但差异无统计学意义。对小鼠的止咳(二氧化硫引咳法)实验表明:保肺颗粒高、中、低剂量均能明显延长SO2引起的小鼠咳嗽潜伏期;高、中剂量能明显减少2 min内咳嗽次数;保肺颗粒高、低剂量能明显延长枸橼酸引起的豚鼠咳嗽潜伏期,能明显减少5 min内咳嗽次数,潜伏期延长率有明显提高。结论:保肺颗粒具有较好的祛痰、平喘、止咳、抗炎作用。

Pharmacodynamics Research on Expectorant, Antiasthmatic, Antitussive and Antiinflammatory Effects of Baofei Granules

To study the expectorant, antiasthmatic, antitussive, and antiinflammatory effects of Baofei Granules. Methods:The mice phenolsulfonphthalein excretion method was used to observe the expectorant effects. The guinea pigs asthma induced by histamine phosphate method was used to observe the antiasthmatic effects. The antitussive effects of the cough reaction in mice caused by SO2, and the anti-inflammatory effects of the auricle swelling caused by xylene, and the anti-inflammatory effects of the rat toe swell method induced by carrageenan were observed. Results:Experiments on mice auricular swelling inflammation model showed the high, medium and low dose groups of Baofei Granules could significantly inhibit the swelling of mice ears caused by xylene, and its swelling degree and swelling rate were significantly reduced; the expectorant(tracheal phenol red method)experiments on mice showed that Baofei Granules can increase the excretion of phenol red in high, medium and low doses. Anti-asthmatic(guinea-spray method)experiments on guinea pigs showed that high doses of Baofei Granules can significantly increase the prolongation rate of guinea pig asthma caused by histamine phosphate, and low and medium doses can also increase the prolongation rate of guinea pig asthma latency, but there was no statistical difference. The relieving cough(sulfur dioxide cough method)experiment on mice showed that high, medium and low doses of Baofei Granule can significantly prolong the incubation period of cough caused by SO2 in mice; high and medium doses can significantly reduce the number of coughs in 2 minutes; high and low Baofei Granules can significantly prolong the incubation period of guinea pig cough caused by citrate, can significantly reduce the number of coughs within 5 minutes, and the prolongation rate of incubation period has been significantly improved. Conclusion:Baofei Granules has significant expectorant, antiasthmatic, antitussive, and antiinflammatory effects.