| 环境因素与肌萎缩侧索硬化相关性的研究进展 |
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| 引用本文： | 张冬梅,丰宏林.环境因素与肌萎缩侧索硬化相关性的研究进展[J].神经疾病与精神卫生,2020,20(3):204-208. |
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| 作者姓名： | 张冬梅 丰宏林 |
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| 作者单位： | 150000 哈尔滨医科大学附属第一医院神经内科;150000 哈尔滨医科大学附属第一医院神经内科 |
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| 基金项目： | 10.3969/j.issn.1009-6574.2020.03.011 |
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| 摘 要： | 肌萎缩侧索硬化是一种常见的致死性神经系统退行性疾病,可分为家族型肌萎缩侧索硬化和散发型肌萎缩侧索硬化.多项研究表明,许多环境和遗传风险因素共同导致了散发型肌萎缩侧索硬化的发生.我国对遗传因素的研究处于起步阶段,且对环境因素的研究相对不足,需要进一步明确.现将对与肌萎缩侧索硬化相关的环境风险因素的作用及机制进行综述.
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| 关 键 词： | 肌萎缩侧索硬化 环境因素 发病机制 氧化应激 综述 |
Research progress on the relationship between environmental factors and amyotrophic lateral sclerosis |
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| Zhang Dongmei,Feng Honglin.Research progress on the relationship between environmental factors and amyotrophic lateral sclerosis[J].Nervous Diseases and Mental Health,2020,20(3):204-208. |
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| Authors: | Zhang Dongmei Feng Honglin |
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| Institution: | (Department of Neurology,the First Affiliated Hospital of Harbin Medical University,Harbin 150000,China) |
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| Abstract: | Amyotrophic lateral sclerosis is a common and fatal neurodegenerative diseases,which can be divided into familial amyotrophic lateral sclerosis and sporadic amyotrophic lateral sclerosis.Several studies have shown that a combination of environmental and genetic risk factors contribute to sporadic amyotrophic lateral sclerosis.The research on genetic factors is in the initial stage in China,and the research on environmental factors is relatively insufficient,which needs to be further clarified.The role and mechanism of environmental risk factors associated with amyotrophic lateral sclerosis are reviewed. |
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| Keywords: | Amyotrophic lateral sclerosis Environmental factors Pathogenesis Oxidative stress Review |
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