酪酸梭菌二联活菌联合诺氟沙星治疗急性肠炎的效果观察

目的 探讨酪酸梭菌二联活菌联合诺氟沙星治疗急性肠炎的临床疗效。方法 选取2015年12月—2018年12月内蒙古师范大学医院收治的急性肠炎患者80例作为研究对象，用随机数字表法将患者分为对照组和观察组，每组各40例。对照组给予诺氟沙星胶囊，首剂量0.4 g，从第2次服用开始逐渐减少剂量，降至0.2 g/次，4次/d。观察组在对照组治疗的基础上口服酪酸梭菌二联活菌胶囊，3粒/次，2次/d。两组均连续治疗7 d。观察两组患者的临床疗效和临床症状改善情况，同时比较两组治疗前后的免疫功能指标水平。结果 治疗后，观察组临床总有效率为92.50%，显著高于对照组的72.50%，两组比较差异具有统计学意义（P<0.05）。治疗后，观察组患者呕吐、腹痛和腹泻消失时间均显著短于对照组，两组比较差异具有统计学意义（P<0.05）。治疗后，观察组的CD3⁺、CD4⁺和CD4⁺/CD8⁺水平显著升高，CD8⁺水平降低（P<0.05）；且观察组治疗后免疫功能指标显著优于对照组（P<0.05）。结论 酪酸梭菌二联活菌联合诺氟沙星可显著缩短急性肠炎患者的症状消失时间、提高免疫功能及临床治疗效果，值得临床借鉴。

Effect observation of combined clostridium butyricum and bifidobacterium combined with norfloxacin in treatment of acute enteritis

Objective To investigate the clinical effect of Combined Clostridium Butyricum and Bifidobacterium Capsules, Live combined with norfloxacin in treatment of acute enteritis. Methods Patients (80 cases) with acute enteritis from December 2015 to December 2018 in The Hospital of Inner Mongolia Normal University were divided into control and observation group by the random number table method, and each group had 40 cases. Patients in the control group were given Norfloxacin Capsules at the first dose of 0.4 g, and gradually reduced the dose from the second dose to 0.2 g/time, four times daily. Patients in the observation group were po administered with Combined Clostridium Butyricum and Bifidobacterium Capsules, Live on the basis of control group, 3 grains/time, twice daily. Both groups were treated continuously for 7 d. The clinical efficacy and improvement of clinical symptoms of patients in two groups were observed, the levels of immune function indexes before and after treatment in two groups were compared. Results After treatment, the total clinical effective rate in the observation group was 92.50%, which was significantly higher than 72.50% in the control group, and the difference between two groups was statistically significant (P<0.05).After treatment, the disappearance time of vomiting, abdominal pain, and diarrhea in the observation group was significantly shorter than that in the control group, and the difference between two groups was statistically significant (P<0.05). After treatment, the levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺ in two groups were significantly increased, but the levels of CD8⁺ were decreased (P<0.05).After treatment, the immune function indexes in the observation group were significantly better than those in the control group (P<0.05). Conclusion Combined Clostridium Butyricum and Bifidobacterium Capsules, Live combined with norfloxacin can significantly shorten the symptom disappearance time of patients with acute enteritis, improve the immune function and clinical therapeutic effect, which is worthy of clinical reference.