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Immunohistochemical staining as supportive diagnostic tool for pseudomyxoma peritonei arising from intraductal papillary mucinous neoplasm: A report of two cases and literature review
Affiliation:1. Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, PA, USA;2. Oncora Medical, Philadelphia, PA, USA;3. Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA;4. Department of Surgery, Division of Thoracic Surgery, University of Maryland Medical Center, Baltimore, MD, USA;5. Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, MD, USA;1. Department of Surgery, Yale School of Medicine, New Haven, CT;2. Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT;3. Department of Medical Sciences, Frank H Netter MD School of Medicine, Quinnipiac University, North Haven, CT;4. Department of Transplantation, Primary Children''s Hospital-Intermountain Healthcare, Salt Lake City, UT;2. Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, TX;3. Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX;4. Departments of Ophthalmology and Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY;5. Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, Galveston, TX;11. Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City, IA;12. Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medical College, New York, NY;1. Academic Teaching Hospital Landshut-Achdorf, Medizinische Klinik II, Landshut, Technische Universität München, Germany;2. Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technische Universität München, München, Germany;3. Institut für diagnostische und interventionelle Radiologie, Klinikums rechts der Isar, Technische Universität München, München, Germany;4. Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, München, Germany;5. Klinik für Innere Medizin I, Universitätsklinikum Ulm, Ulm, Germany
Abstract:Background/ObjectivesPseudomyxoma peritonei (PMP) arising from an intraductal papillary mucinous neoplasm of the pancreas (IPMN) is a rare condition. The diagnosis of IPMN as the origin of PMP is mainly inferred from the clinical course and the exclusion of PMP from other organs. The pathological diagnosis has not yet been established. To evaluate the usefulness of immunohistochemical staining for the diagnosis of the primary lesion of PMP as IPMN.MethodsThere are 2 cases of PMP arising from IPMN between March 2010 and December 2019 at National Center for Global Health and Medicine. A PubMed search that reported PMP arising from IPMN identified 16 additional cases. Diagnostic methods and clinicopathological features of 18 cases were compared.ResultsFour cases including our two cases used immunohistochemical staining for the diagnosis of PMP arising from IPMN. The correspondence of the immunohistochemical staining between PMP and IPMN was shown in the three cases including previously reported two cases and one of our two cases to identify the primary lesion of PMP as IPMN. In addition, we revealed that the comparison of the immunostaining pattern of PMP with the representative immunostaining pattern of the candidate primary lesions is helpful for the diagnosis of the primary lesion of PMP.ConclusionsImmunohistochemical staining is helpful to identify the primary lesion of PMP as IPMN.
Keywords:Immunohistochemical staining  Intraductal papillary mucinous neoplasm (IPMN)  Mucinous neoplasm  Pseudomyxoma peritonei (PMP)
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