Histological diagnosis and grading of pancreatic neuroendocrine tumor by endoscopic ultrasound-guided fine needle biopsy using a 25-gauge needle with a core trap: A multicenter prospective trial |
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| Affiliation: | 1. Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan;2. Departments of Cancer Survey and Gastrointestinal Oncology, Osaka International Cancer Institute, Japan;3. Department of Surgical Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan;4. Department of Diagnostic Pathology, Japanese Red Cross Kyoto Daini Hospital, Japan;5. Clinical Research Center, Kindai University Hospital, Japan;6. Department of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Japan;7. Department of Gastroenterology, Osaka City General Hospital, Japan;8. Department of Gastroenterology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Japan;9. Third Department of Internal Medicine, Kansai Medical University, Japan;10. Second Department of Internal Medicine, Osaka Medical College, Japan;11. Division of Gastroenterology, Department of Internal Medicine, Graduate School of Medicine, Kobe University, Japan;12. Department of Gastroenterology and Hepatology, Japanese Red Cross Osaka Hospital, Japan;13. Department of Medicine, Division of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan;14. Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Japan;15. Department of Diagnostic Pathology, Japanese Red Cross Kyoto Daiichi Hospital, Japan;p. Second Department of Internal Medicine, Wakayama Medical University School of Medicine, Japan;1. Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India;2. Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India;3. Department of Surgical Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India;4. Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India;5. Department of Nephrology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India;1. Department of Hepatobiliary and Pancreatic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan;2. Department of Cancer Survey, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan;3. Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan;1. Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-0012, Japan;2. Clinical Study Support Center, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-0012, Japan;3. Department of Radiology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-0012, Japan;4. Second Department of Surgery, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-0012, Japan |
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| Abstract: | ObjectivesPreoperative grading of pancreatic neuroendocrine tumors (PanNET) is challenging. The aim of this study was to prospectively evaluate the use of a 25-gauge needle with a core trap for diagnosis and grading of PanNET.MethodsThis multicenter prospective trial was registered with the University Hospital Medical Information Network (UMIN000021409). Consecutive patients with suspected PanNET between June 2016 and November 2017 were enrolled. All patients underwent endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) using a 25-gauge needle with a core trap. Samples obtained after the first needle pass were used for central pathological review. EUS-FNB was evaluated in terms of (i) technical success rate, (ii) adequacy for histological evaluation, (iii) complication rate during the procedure, and (iv) concordance between PanNET grading on EUS-FNB and that after analysis of the resected tumor.ResultsFifty-two patients were enrolled. Of the 36/52 patients who underwent surgical resection, 31 were finally diagnosed with PanNET and were eligible for analysis. The technical success rate of EUS-FNB was 100%. The rate of adequacy for histological evaluation was 90.3%. There were no complications related to EUS-FNB. The concordance rate between PanNET grading on EUS-FNB and that after analysis of the resected tumor was 82.6% (95% confidence interval = 61.22–95.05, P = 0.579).ConclusionsEUS-FNB using a 25-gauge needle with a core trap is feasible, providing histological samples are of sufficient quality for diagnosis and grading of PanNET. |
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| Keywords: | Core trap Endoscopic ultrasound-guided fine needle aspiration Endoscopic ultrasound-guided fine needle biopsy Grading Pancreatic neuroendocrine tumor EUS-FNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" endoscopic ultrasound-guided fine needle aspiration EUS-FNB" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" endoscopic ultrasound-guided fine needle biopsy PanNET" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" pancreatic neuroendocrine tumor |
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