Interneuronal networks mediate cortical inhibition and facilitation |
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| Affiliation: | 1. Westmead Clinical School, University of Sydney, Australia;2. Brain and Mind Center, University of Sydney, Australia;1. School of Women’s and Children’s Health, UNSW Medicine, UNSW Sydney, Australia;2. Department of Neurology, Sydney Children’s Hospital, Australia;3. Kids Cancer Centre, Sydney Children’s Hospital, Australia;4. Brain & Mind Centre, University of Sydney, Australia;5. Prince of Wales Clinical School, UNSW Medicine, UNSW Sydney, Australia;1. Non-Invasive Brain Stimulation Unit/Department of Behavioral and Clinical Neurology, Santa Lucia Foundation, Via Ardeatina 354, 00179 Rome, Italy;2. Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, Queen Square 33, WC1N 3BG London, United Kingdom;3. Department of System Medicine, University of Tor Vergata, Via Oxford 81, 00133 Rome, Italy;1. Discipline of Physiology, Adelaide Medical School, The University of Adelaide, Adelaide, Australia;2. Department of Neurology & Stroke, and Hertie-Institute for Clinical Brain Research, Eberhard Karls University of Tübingen, Tübingen, Germany;1. Institute of Neurology, Department of Geriatrics, Neuroscience and Orthopedics, Catholic University, Policlinic A. Gemelli, Rome, Italy;2. Department of Neurology, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia;3. Division of Neurology, Toronto Western Research Institute, University of Toronto, Toronto, Ontario, Canada;4. Human Cortical Physiology and Neurorehabilitation Section, NINDS, NIH, Bethesda, MD, USA;5. Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada;6. Department of Neurology, University Campus Bio-medico, Rome, Italy;7. Department of Clinical Neurophysiology, University of Eastern Finland, Kuopio, Finland;8. Monash Alfred Psychiatry Research Centre, Monash University Central Clinical School and The Alfred, Melbourne, Australia;9. Medical University of South Carolina, Ralph H. Johnson VA Medical Center, Charleston, SC, USA;10. Human Motor Control Section, Medical Neurology Branch, NINDS, NIH, Bethesda, MD, USA;11. Department of Physiology, Henri Mondor Hospital, Assistance Publique – Hôpitaux de Paris, Créteil, France;12. EA 4391, Nerve Excitability and Therapeutic Team, Faculty of Medicine, Paris Est Créteil University, Créteil, France;13. Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany;14. Department of Neurology, Japanese Red Cross Medical Center, Tokyo, Japan;15. Department of Clinical and Experimental Sciences University of Brescia, Brescia, Italy;p. IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy;q. Department of Clinical Neurophysiology, University Medical Center Göttingen, Georg-August-University, Göttingen, Germany;r. Berenson-Allen Center for Non-invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;s. Department of Clinical Neurophysiology, Georg-August University, Göttingen, Germany;t. Brain Investigation & Neuromodulation Lab, Unit of Neurology and Clinical Neurophysiology, Department of Neuroscience, University of Siena, Siena, Italy;u. Institute of Neurology, University College London, London, United Kingdom;v. Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark;w. Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark;x. Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan;y. Institute of Cognitive Neuroscience, University College London, London, United Kingdom;z. Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard Karls University, Tübingen, Germany;1. Department of Clinical and Experimental Medicine, University of Messina, Italy;2. Department of Neurology, Humanitas Research Hospital, Rozzano, Milan, Italy;3. Department of Biomedical Science and Morphological and Functional Images, University of Messina, Italy;4. IRCCS Centro “Bonino Pulejo”, Messina, Italy;5. Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark;6. Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark;7. Institute for Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark |
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| Abstract: | ObjectiveRecruitment of interneuronal circuits generating later indirect (I) waves seem to be important in short-interval intracortical inhibition (SICI) and facilitation (SICF) development. This study assessed whether individual variations in intracortical inhibition and facilitation could be explained by variation in recruitment of interneuronal networks.MethodsCortical excitability was assessed using a figure of eight coil, with motor evoked responses recorded over the contralateral abductor pollicis brevis (APB) muscle. I-wave recruitment was inferred from the measurement of motor evoked potential (MEP) onset latencies, with coil positioned in posterior-to-anterior (early I waves) and anterior-to-posterior (later I waves) directions.ResultsSubtle variability in the recruitment of later I-waves (I3) was evident across subjects. Importantly, mean SICI (P < 0.05) was significantly greater in subjects recruiting I3 waves, as were the two SICI peaks at interstimulus intervals of 1 ms (P < 0.05) and 3 ms (P < 0.05). In addition, mean SICF was significantly greater in participants exhibiting an AP-to-LM latency differences of <4 ms (P < 0.01). There was no significant correlation between I-wave recruitment and intracortical facilitation, motor evoked potential amplitude or cortical silent period duration.ConclusionsDifferential recruitment of interneuronal networks appears to underlie the generation and individual variations in intracortical inhibition and facilitation.SignificanceInvestigating cortical interneuronal networks in human diseases may yield novel pathophysiological insights. |
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| Keywords: | Indirect wave MEP latency Short interval intracortical facilitation Short interval intracortical inhibition |
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