Event-related potential changes due to early-onset Parkinson’s disease in parkin (PARK2) gene mutation carriers and non-carriers |
| |
Affiliation: | 1. Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, 34093 Capa, Istanbul, Turkey;2. Department of Physiology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Atasehir 34752, Istanbul, Turkey;3. Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, 34093 Capa, Istanbul, Turkey;4. Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, 34093 Capa, Istanbul, Turkey;5. Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, 72076 Tübingen, Germany;6. German Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany;7. Hulusi Behcet Life Sciences Research Laboratory - Neuroimaging Unit, Istanbul University, 34093 Capa-Istanbul, Turkey |
| |
Abstract: | ObjectiveTo investigate cognitive functions in non-demented patients with early-onset Parkinson's disease (PD), and to compare PARK2 gene mutation carriers and non-carriers by means of event-related brain potentials (ERPs).MethodsThe participants comprised patients with early-onset PD (EOPD) and healthy controls (HC). Patients with EOPD were divided into two groups as carriers of known pathogenic variants of PARK2 gene (EOPD-PC) and non-carriers of genes involved in familial PD (EOPD-NC). ERP data were collected during auditory oddball and visual continuous performance test (CPT).ResultsBoth EOPD groups (EOPD-PC and EOPD-NC) displayed reduced and delayed P3 in response to oddball target and CPT NoGo. CPT Go P3 was reduced in EOPD-NC but not in EOPD-PC. Oddball target N1 was reduced and P2 was enhanced in both EOPD-PC and EOPD-NC. In both cognitive tasks, RTs were prolonged and accuracy was lower in EOPD-PC and EOPD-NC.ConclusionsWe found several EOPD-related neurophysiologic changes, implying impairments in cognitive functions. Pairwise comparisons between EOPD-PC and EOPD-NC revealed no significant ERP marker.SignificanceIn this study, the confounding effect of normative aging was somewhat excluded compared with many previous studies. In contrast with the many oddball studies in non-demented PD, we clearly observed reduced and prolonged P3 in early-onset PD. Our NoGo P3 findings also contribute to the limited ERP research concerning response inhibition. |
| |
Keywords: | Event-related potentials Early-onset Parkinson’s disease Parkin (PARK2) gene mutation |
本文献已被 ScienceDirect 等数据库收录! |
|