| 山莨菪碱的抗心律失常作用 |
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| 引用本文： | 陈锦明,谷淑玲. 山莨菪碱的抗心律失常作用[J]. 药学学报, 1988, 23(11): 857-859 |
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| 作者姓名： | 陈锦明 谷淑玲 |
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| 作者单位： | 徐州医学院药理学教研室(陈锦明)，徐州医学院药理学教研室(谷淑玲) |
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| 摘 要： | 山莨菪碱(anisodamine,简称Ani)有阻断M受体和α受体等作用。近年来,有人报道Ani有钙拮抗作用,这可能与茛菪碱类药物用于治疗心律失常有关。本文采用七种实验动物模型,观察了Ani的抗心律失常作用。
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| 关 键 词： | 山莨菪碱 抗心律失常作用 |
| 收稿时间： | 1987-10-14 |
ANTIARRHYTHMIC EFFECTS OF ANISODAMINE |
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| JM Chen and SL Gu. ANTIARRHYTHMIC EFFECTS OF ANISODAMINE[J]. Acta pharmaceutica Sinica, 1988, 23(11): 857-859 |
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| Authors: | JM Chen and SL Gu |
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| Abstract: | Intraperitoneal injection of anisodamine (Ani) 0.5～10 mg/kg delayed the latent period and shortened the duration of arrhythmia elicited by adrenaline in rabbits, and by aconitine or BaCl2 in rats. The drug was also found to increase markedly the ouabain dosage necessary to induce ventricular premature beats, ventricular tachycardia, ventricular fibrillation and cardiac arrest in guineapigs. In mice given Ani 5～10 mg/kg ip, the incidence of Ach-CaCl2 induced ventricular fibrillation (or flutter) was decreased. The incidence of CaCl2 arrhythmia induced in rats was also decreased by prior administration of the drug. |
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| Keywords: | Anisodamine Antiarrhythmic effects |
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