| 树舌多糖对胃黏膜损伤大鼠胃黏膜PGE2含量及血流量和黏液分泌的影响 |
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| 引用本文： | 杨明,孙红,于德伟,崔志勇,田杰. 树舌多糖对胃黏膜损伤大鼠胃黏膜PGE2含量及血流量和黏液分泌的影响[J]. 中国中药杂志, 2005, 30(15): 1176-1178 |
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| 作者姓名： | 杨明 孙红 于德伟 崔志勇 田杰 |
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| 作者单位： | 吉林省中医中药研究院中药研究所 吉林长春130021(杨明，孙红，于德伟，崔志勇)，长春医学高等专科学校 吉林长春130031(田杰) |
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| 基金项目： | 国家中医药管理局新药开发专项课题（D1X009A）;吉林省科技发展计划重点项目（20030916-6） |
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| 摘 要： | 目的:研究树舌多糖对大鼠胃黏膜损伤的保护作用及其机制。方法:采用醋酸法和幽门结扎法复制大鼠胃溃疡模型,分别测定胃黏膜PGE2含量和胃黏膜血流量及胃黏液分泌。结果:与模型对照组比较,多次灌服树舌多糖250～1000mg·kg-1可明显增加大鼠胃黏膜PGE2含量和胃黏膜血流量,对大鼠胃内游离黏液和胃壁黏液的分泌也具有显著的增加作用,且有明显量效关系。结论:树舌多糖通过提高胃黏膜PGE2含量和胃黏膜血流量及胃黏液分泌来加强胃黏膜屏障,这是其保护胃粘膜损伤的作用机制之一。
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| 关 键 词： | 树舌多糖 抗溃疡 PGE2 胃黏膜血流量 胃黏液 |
| 文章编号： | 1001-5302（2005）15-1176-03 |
| 收稿时间： | 2005-01-25 |
| 修稿时间： | 2005-01-25 |
Effects of the polysaccharides isolated from ganoderma applanatum(PGA)on the level of PGE2 and gastric mucosal blood flow(GMBF) and gastric mucus secretion of rats with gastric mucosa injury |
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| YANG Ming;SUN Hong ;YU De-wei;CUI Zhi-Yong;TIAN Jie. Effects of the polysaccharides isolated from ganoderma applanatum(PGA)on the level of PGE2 and gastric mucosal blood flow(GMBF) and gastric mucus secretion of rats with gastric mucosa injury[J]. China Journal of Chinese Materia Medica, 2005, 30(15): 1176-1178 |
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| Authors: | YANG Ming SUN Hong YU De-wei CUI Zhi-Yong TIAN Jie |
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| Affiliation: | Department of Pharmacology, Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine and Materia Medica, Changchun 130021, China. yming0918@sina.com |
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| Abstract: | Objective: To investigate the protective effects of the polysaccharides isolated from ganoderma applanatum(PGA)on gastric mucosal injury in rats and the underlying mechanism. Method: Gastric ulcer was induced by either acetic acid or pylorus ligation in the rats. The level of PGE2 and GMBF, and gastric mucus secretion were examined respectively. Result: After oral administration of PGA (250-1 000 mg·kg-1) repeatedly, the level of PGE2 and GMBF were obviously increased in gastric mucosa of rats as compared with the model group. The secretions of both free mucus in stomach and mucus of gastric wall were enhanced apparently by PGA in a dose-dependent manner. Conclusion: PGA could strengthen gastric mucosa barrier by improving the level of PGE2, GMBF and the secretion of gastric mucus, which may be one of the mechanisms underlying the protective effect of PGA on the gastric mucosa during the gastric ulcer. |
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| Keywords: | polysaccharides isolated from ganoderma applanatum(PGA) anti-ulcer PGE gastric mucosa blood flow gastric mucus |
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