Effect of alcohol administration on plasma growth hormone response to insulin-induced hypoglycemia. |
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| Authors: | H A Priem B C Shanley C Malan |
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| Institution: | Department of Chemical Pathology, Faculty of Medicine, University of Stellenbosch, Parowvallei, South Africa. |
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| Abstract: | Plasma growth hormone (HGH) response to insulin-induced hypoglycemia was assessed in a group of normal adult volunteers, with and without prior consumption of ethanol. A significant difference was found in peak HGH concentrations on the two occasions, indicating that prior consumption of ethanol attenuates the normal HGH response to insulin-induced hypoglycemia. It is suggested that ethanol may deplete catecholamine stores in the neurons of the ventromedial nucleus of the hypothalamus and may thereby impair secretion of growth hormone releasing factor. Under certain circumstances this could be of importance in the pathogenesis of alcohol-induced hypoglycemia. |
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| Keywords: | Reprint requests should be addressed to Professor B C Shanley Department of Chemical Pathology Faculty of Medicine University of Stellenbosch P O Box 63 Parowvallei South Africa |
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