| 星点设计-效应面法优化环维黄杨星D醇质体的制备 |
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| 引用本文： | 于洋,周莉玲,李秀梅.星点设计-效应面法优化环维黄杨星D醇质体的制备[J].中国医院药学杂志,2010(3). |
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| 作者姓名： | 于洋 周莉玲 李秀梅 |
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| 作者单位： | 广州中医药大学; |
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| 摘 要： | 目的:优化环维黄杨星D醇质体的处方。方法:以包封率和平均粒径为评价指标,采用星点设计-效应面法优化醇质体处方中大豆磷脂、药物和无水乙醇的最佳配比。结果:以各因素分别对评价指标建立二项式拟合方程,结合效应面法确定了优化处方中大豆磷脂-药物-无水乙醇为2.85%∶0.65%∶35.5%。结论:建立的模型可较好地描述该实验中因素与指标的关系,预测性良好。
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| 关 键 词： | 环维黄杨星D 醇质体 星点设计 效应面法 |
Optimized preparation of cyclovirobuxine D ethosomes by central composite design/response surface methodology |
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| YU Yang,ZHOU Li-ling,LI Xiu-mei.Optimized preparation of cyclovirobuxine D ethosomes by central composite design/response surface methodology[J].Chinese Journal of Hospital Pharmacy,2010(3). |
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| Authors: | YU Yang ZHOU Li-ling LI Xiu-mei |
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| Institution: | YU Yang,ZHOU Li-ling,LI Xiu-mei(Guangzhou University of Traditinal Chineses Medicine,Guangdong Guangzhou 510360,China) |
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| Abstract: | OBJECTIVE To optimize the preparation of cyclovirobuxine D ethosomes.METHODS Taking encapsulated ratio and average diameter as evaluation index to optimize the best matching of soybean phospholipid,drug and absolute alcohol in ethosomes.RESULTS The soybean phospholipid,drug and absolute alcohol in ethosomes was 2.85%,0.65% and 35.5% respectively by establishing second-order quadratic models of index and combining with response surface methodology.CONCLUSION In this experiment,the established model can descr... |
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| Keywords: | cyclovirobuxine D ethosomes central composite design response surface methodology |
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