抗室性心律失常药物的成本-效果分析

目的 对口服抗室性心律失常药物进行药物经济学评价,为合理选择抗室性心律失常药物治疗方案提供参考.方法 通过文献检索,汇总了10种抗室性心律失常药有效性、安全性的信息;以各种药物每月药费范围上限为成本,有效率为效果,进行成本-效果分析及敏感度分析.结果 抗室性心律失常药总有效率是78.71％,药物不良反应率为13.97％;成本-效果比较低的药物依次是美西律＜阿替洛尔＜普罗帕酮＜胺碘酮＜索他洛尔＜美托洛尔＜比索洛尔;成本-效果比较高的药物依次是莫雷西嗪＞稳心颗粒＞参松养心胶囊.药物不良反应率较低的药物依次是比索洛尔＜参松养心胶囊＜稳心颗粒＜阿替洛尔＜美托洛尔;药物不良反应率较高的药物依次是索他洛尔＞莫雷西嗪＞美西律＞胺碘酮＞普罗帕酮.结论 阿替洛尔、美托洛尔、比索洛尔属高效价廉安全的抗室性心律失常药,在药物经济学中鼓励使用高效低成本及安全的药物.

Cost-effectiveness analysis of anti-ventricular arrhythmia drugs

Objective To evaluate the pharmacoeconomical outcome of anti-ventricular arrhythmia drugs,to provide reference for national selection of anti-ventricular arrhythmia drugs.Methods By searching literatures,collected the information of efficacy and safety of 10 kinds of anti-ventricular arrhythmia drugs; took the top limit of monthly expense as cost and efficiency as effectiveness to do cost-effectiveness analysis and sensitivity analysis.Results The total effective rate of anti-ventricular arrhythmia medicine was 78.71%,and drug adverse reaction rate was 13.97%.The low cost-effectiveness drugs were mexiletine 〈 atenolol 〈 propafenone 〈 amiodarone 〈 sotolol 〈 metoprolol 〈 bisoprolol; the high cost-effectiveness drugs were moracizine 〉 Wenxin grannle 〉 SRYX capsule; the low ADR rate drugs were bisoprolol 〈 SRYX capsule 〈 Wenxin grannle 〈 atenolol 〈 metoprolol; the high ADR rate drugs were sotolol 〉 moracizine 〉 mexiletine 〉 amiodarone 〉 propafenone.Conclusion Atenolol,metoprolol,bisoprolol belong to high efficient,safe and low cost medicine.In the drug economics we encourage to use high efficient,safe and low cost drugs.