| 兔角膜严重碱烧伤后氧化型谷胱甘肽与胶原降解关系的实验研究 |
| |
| 引用本文： | 李立 汪湘琳. 兔角膜严重碱烧伤后氧化型谷胱甘肽与胶原降解关系的实验研究[J]. 眼外伤职业眼病杂志, 1994, 16(4): 250-253 |
| |
| 作者姓名： | 李立 汪湘琳 |
| |
| 作者单位： | 重庆医科大学附二院眼科，重庆医科大学附一院眼科 630010 |
| |
| 摘 要： | 本文探讨了氧化型谷胱甘肽（ＧＳＳＧ）在角膜碱烧伤中对胶原降解的作用机制和实验治疗影响。结果表明：角膜碱烧伤后治疗组和对照组在第３天时ＧＳＳＧ均增高（Ｐ＜０．０１），而羟脯氨酸下降（Ｐ＜０．０１）。８天后ＧＳＳＧ逐渐下降，羟脯氨酸则逐渐增高。３０天时２组均基本恢复正常（Ｐ＞０．０５）。ＧＳＳＧ与羟脯氨酸呈负向变化关系。
|
| 关 键 词： | 碱烧伤 谷胱甘肽 羟脯氨酸 胶原酶 角膜损伤 |
Oxidized glutathione and collagcnous deg-radation and the treatment with vitamine C and citrate after severe alkali-burned cornea inrabbit |
| |
| Li Li. Wang Xianglin. Oxidized glutathione and collagcnous deg-radation and the treatment with vitamine C and citrate after severe alkali-burned cornea inrabbit[J]. Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries, 1994, 16(4): 250-253 |
| |
| Authors: | Li Li. Wang Xianglin |
| |
| Affiliation: | Li Li. Wang Xianglin. Department of Ophtlwlmology,the Second Hospital of Chongqing Medical University,Chongqing,China,630010 |
| |
| Abstract: | The author studied the mechanism and the affection of experimental treatment after severe alkali-burned cornea in rabbit. The results showed that in both of the control and the treatment groups the level of oxidized glutathione increased (P<0.01) within 3 days and decreased gradually 8th day after injury; hydroxyproline decreased on the 3th day (P<0.01) but increased gradually 8 days after injury. On the 30th day the levels of both oxidized glutathione and hydroxyproline returned to the normal level (P>0.05). The level changing between oxidized glutathione and hydroxyproline was converse. |
| |
| Keywords: | Alkali-burned cornea Collagenase Hydroxyproline Oxidized glutathione Disulfide-thiol Vitamine C Citrate. |
| 本文献已被 CNKI 维普 等数据库收录！ |
