| The influence of ultraviolet blood irradiation and oxygenation on oxygen free radicals metabolism in rabbits with soman intoxication |
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| 作者姓名： | 张献清 张晓迪 穆士杰 陈蕤 夏爱军 梁欣 海春旭 |
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| 作者单位： | [1]Department of Blood Transfusion, Xijing Hospital, Fourth Military Medical University, Xi＇an 710033,China [2]Department of Toxicology, Fourth Military Medical University, Xi＇an 710033, China |
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| 摘 要： | Objective： To investigate the effect of ultraviolet blood irradiation and oxygenation （UBIO） on the metabolism of oxygen free radicals in rabbits with acute soman intoxication. Methods： One hundred rabbits were randomly divided into 5 groups： normal control group, intoxication group, routine therapy group, UBIO therapy group and combined therapy group. After 14 d, the concentration of malondiadehyde （MDA） and activity of superoxide dismutase（SOD）, glutathionperoxidase（GSH-Px）, catalase （CAT） and total antioxidative capacity （T-AOC） in serum were determined respectively. Results： Compared with the normal control group, the concentration of MDA and activity of CAT in the intoxication group were significantly higher （P 〈 0. 05）, but SOD, GSH-Px activity and T-AOC were significantly lower （P〈0.05）. After UBIO or combined therapy, serum MDA level was significantly lower in comparison with intoxication group （P〈0.05）, but the activity of SOD, GSH-Px, CAT and T-AOC were higher than intoxication group （P（0.05）. Conclusion： There is an obvious oxygen free radical injury in rabbits with acute soman intoxication. UBIO can improve the antioxidation ability of rabbits and may be applied to treat acute soman intoxication as adjunctive therapy.
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| 关 键 词： | 紫外线 血液照射 氧合作用 代谢作用 甲氟磷酸异已酯 |
| 收稿时间： | 2005-10-05 |
| 修稿时间： | 2006-01-10 |
The influence of ultraviolet blood irradiation and oxygenation on oxygen free radicals metabolism in rabbits with soman intoxication |
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| ZHANG Xian-qing,ZHANG Xiao-di,MU Shi-jie,CHEN Rui,XIA Ai-jun,LIANG Xin,HAI Chun-xu.The influence of ultraviolet blood irradiation and oxygenation on oxygen free radicals metabolism in rabbits with soman intoxication[J].Journal of Medical Colleges of PLA(China),2006,21(1):42-44. |
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| Authors: | ZHANG Xian-qing ZHANG Xiao-di MU Shi-jie CHEN Rui XIA Ai-jun LIANG Xin HAI Chun-xu |
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| Abstract: | Objective:To investigate the effect of ultraviolet blood irradiation and oxygenation (UBIO) on the metabolism of oxygen free radicals in rabbits with acute soman intoxication. Methods: One hundred rabbits were randomly divided into 5 groups: normal control group, intoxication group, routine therapy group. UBIO therapy group and combined therapy group. After 14 d, the concentration of malondiadehyde(MDA) and activity of superoxide dismutase(SOD), glutathionperoxidase(GSH-Px), catalase (CAT) and total antioxidative capacity (T-AOC) in serum were determined respectively. Results: Compared with the normal control group, the concentration of MDA and activity of CAT in the intoxication group were significantly higher (P < 0. 05). but SOD. GSH-Px activity and T-AOC were significantly lower (P<0. 05). After UBIO or combined therapy, serum MDA level was significantly lower in comparison with intoxication group (P<0. 05). but the activity of SOD. GSH-Px, CAT and T-AOC were higher than intoxication group(P<0. 05). Conclusion: There is an obvious oxygen free radical injury in rabbits with a-cute soman intoxication. UBIO can improve the antioxidation ability of rabbits and may be applied to treat acute soman intoxication as adjunctive therapy. |
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| Keywords: | blood irradiation and oxygenation ultraviolet soman intoxication oxygen free radical |
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