| 口腔粘膜下纤维化组织中内皮素1的免疫电镜研究 |
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| 引用本文： | 许春姣,彭解英,刘蜀凡,方厂云,彭隆祥,徐锡萍. 口腔粘膜下纤维化组织中内皮素1的免疫电镜研究[J]. 中华口腔医学杂志, 2000, 35(3): 215-217,I016 |
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| 作者姓名： | 许春姣 彭解英 刘蜀凡 方厂云 彭隆祥 徐锡萍 |
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| 作者单位： | 1. 湖南医科大学附属湘雅医院口腔科,长沙,410008
2. 湖南医科大学电镜室 |
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| 基金项目： | 湖南省科委发展基金!( 99ssy2 0 0 2 14 ) |
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| 摘 要： | 目的 观察内皮素（ＥＴ－１）在人口腔粘膜下纤维（ＯＳＦ）组织中的形态学定位,并探讨ＥＴ－１与ＯＳＦ病理学的关系。方法 用免疫电镜技术检测ＥＴ－１在ＯＳＦ组织中的超微结构定位。结果 ＥＴ－１免疫阳性颗粒主要存在于ＯＳＦ组织的上皮细胞、成纤维细胞及内皮细胞的胞浆内。正常口腔粘膜组织中未发现ＥＴ－１免疫阳性颗粒。ＯＳＦ组织中,上皮细胞内的ＥＴ－１阳性颗粒定位于细胞膜上,胞浆内的阳性颗粒可能定位于粗面内质
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| 关 键 词： | 口腔粘膜下纤维化 SOF 免疫电子显微镜 内皮素1 |
Localization of endothelin-1 in biopsies from oral submucous fibrosis:immunoelectron microscopic study |
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| C Xü,X Peng,S Liu. Localization of endothelin-1 in biopsies from oral submucous fibrosis:immunoelectron microscopic study[J]. Chinese journal of stomatology, 2000, 35(3): 215-217,I016 |
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| Authors: | C Xü X Peng S Liu |
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| Affiliation: | Department of Stomatology, Xiangya Hospital, Hunan Medical University, Changsha 410008, China. |
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| Abstract: | Objective To determine the endothelin 1 ( ET 1)immunoreactivity in biopsies from human oral submucous fibrosis (OSF)and to investigate the relation between ET 1 and OSF Methods The localization of ET 1 in biopsies from OSF was observed with immunoelectron microscopic techniques Results High density deposits existed predominantly in the cytoplasm of epithelial cells, fibroblasts and endothelial cells, but not found in the biopsies of normal controls In the biopsies of OSF, high density granules were lined on the cell membrane ,possibly on the rough endoplsamic reticulum and the mitochondria of the epithelial cells and of the fibroblasts But a few granules were seen in the cytoplasm of the endothelial cells of microvesseles Conclusion ET 1 is one of the pathogenetic factors of OSF |
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| Keywords: | Endothelin 1 Oral submucous fibrosis Microscopy immunoelectron |
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