| 维生素E琥珀酸酯对人鼻咽癌CNE2细胞增殖、凋亡影响的实验研究 |
| |
| 引用本文： | 何金年,姚东方,李杰恩.维生素E琥珀酸酯对人鼻咽癌CNE2细胞增殖、凋亡影响的实验研究[J].广西医科大学学报,2011,28(1):52-54. |
| |
| 作者姓名： | 何金年 姚东方 李杰恩 |
| |
| 作者单位： | 广西医科大学第一附属医院耳鼻咽喉-头颈外科,南宁,530021 |
| |
| 摘 要： | 目的:探讨维生素E琥珀酸酯(Vitamin E Succinate,VES)在体外对人鼻咽癌CNE2细胞的生长抑制作用.方法:以5,10,20,40 mg/L浓度的VES作用于人鼻咽癌CNE2细胞,使用光镜、透射电镜、MTT法、流式细胞仪观察和检测作用24,48,72 h后细胞形态、增殖、凋亡及细胞周期分布情况.结果:...
|
| 关 键 词： | 维生素E琥珀酸酯 鼻咽癌 凋亡 |
STUDY ON THE EFFECT OF VITAMIN E SUCCINATE ON PROLIFERATION AND APOPTOSIS IN HUMAN NASOPHARYNGEAL CARCINOMA CELL LINE CNE2 |
| |
| He Jinnian,Yao Dongfang,Li Jieen.STUDY ON THE EFFECT OF VITAMIN E SUCCINATE ON PROLIFERATION AND APOPTOSIS IN HUMAN NASOPHARYNGEAL CARCINOMA CELL LINE CNE2[J].Journal of Guangxi Medical University,2011,28(1):52-54. |
| |
| Authors: | He Jinnian Yao Dongfang Li Jieen |
| |
| Institution: | .(Department of Otorhinolaryngology Head and Neck Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China) |
| |
| Abstract: | Objective：To study the effect of Vitamin E Succinate（VES） on nasopharyngeal carcinoma cell line CNE2 in vitro.Methods：CNE2 cells were treaded with 5,10,20,40 mg/L concentrations of VES,the cell morphous,proliferation inhibition rate,apoptosis ratio and cell cycle status were detected by MTT,microscope,transmission election microscopy（TEM）,flow cytometry after 24,48,72 h;respectively.Results：The CNE2 proliferation was inhibited in a dose-and time-dependent manner and apoptosis was induced after treated by VES,and showed typical apoptosis characteristics in microscope and TEM.CNE2 cells showed G0/G1 phase blockage in a dose-dependent way 48 hours after the treatment of VES.Conclusion：VES could inhibit the proliferation of CNE2 cells in vitro and the mechanism may relate to its preventing the cell cycle in G0/G1 phase,and potential anti nasopharyngeal carcinoma. |
| |
| Keywords: | vitamin E succinate nasopharyngeal carcinoma apoptosis |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
