Changes in the count of pancreatic beta- and alpha-cells and blood glucose level in rats with alloxan-induced diabetes |
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| Authors: | Aleeva G N Kiyasov A P Minnebaev M M Burykin I M Khafiz'yanova R Kh |
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| Affiliation: | (1) Department of Normal Human Anatomy, Department of Pathophysiology, Department of Pharmacology, Kazan State Medical University, Russia |
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| Abstract: | We estimated the count of pancreatic alpha- and beta-cells and blood glucose level at various stages of alloxan-induced diabetes in rats. Alloxan decreased the count of insulin-producing beta-cells, but increased the number of glucagon-secreting alpha-cells in the pancreas (week 1 of diabetes). These changes were accompanied by hyperglycemia. The decrease in blood glucose level in diabetic rats was associated with an increase in beta-cell count against the background of high density of pancreatic alpha-cells. |
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| Keywords: | pancreas alpha-cells beta-cells diabetes alloxan |
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