帕金森病患者躯体疲劳与运动功能的相关性分析

目的 观察帕金森病(PD)患者躯体疲劳症状与运动功能的相关性.方法 按照统一的入选和排除标准,选取36例诊断明确的老年PD患者,其中男性22例,女性14例;同时选取年龄、性别相匹配的健康人18名作为对照,分别进行PD疲劳量表评定(PFS)、起立行走时间、6min最大步行距离试验.对比两组评测结果,在PD组内对PFS得分与运动功能水平进行相关性分析.结果 PFS得分、起立行走时间和6 min最大步行距离在PD组与健康对照组之间差异有统计学意义(P＜0.05);PD患者PFS得分与起立行走时间存在正相关性(r=0.82,P＜0.01),和6 min最大行走距离呈负相关(r=-0.61,P＜0.01); 结论与年龄性别相匹配的健康人相比,PD患者存在明显的躯体疲劳症状;PD患者躯体疲劳症状与运动功能减退呈正相关.

Correlation analysis between physical fatigue and motor function in patients with Parkinson's disease

Objective To observe the correlation between physical fatigue and motor function in patients with Parkinson's disease (PD). Methods The 36 patients (12 females, 22 males) with PD were elected from PD clinic in Beijing Hospital, and 18 health controls of age and gender matching were enrolled. The Parkinson Fatigue Scale (PFS), the timed get up and go test and the six-minute walk test were used to evaluate the disease progress, physical fatigue and motor function. The correlation between PFS score and motor function was analyzed. Results There were significant differences between patients with PD and healthy controls in PFS score, get up and Go performance time and the max six-minute walk distance (P＜0.05). In patients with PD, the PFS score was positively correlated with get up and go performance time (r= 0.82, P＜0. 01 ), and was negatively correlated with distance of six-minute walk (r= -0. 61, P＜0. 01). Conclusions Patients with PD show more fatigability and decreased motor function compared with healthy people of age and gender matching; The severity of physical fatigue symptom of patients with PD shows positive correlation with get up and go performance time, and negative correlation with the distance of six-minute walk.