Role of macrophage migration inhibitory factor in hepatitis B virus-specific cytotoxic-T-lymphocyte-induced liver injury |
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| Authors: | Kimura Kiminori Nagaki Masahito Nishihira Jun Satake Shinichi Kuwata Kazuo Moriwaki Hisataka |
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| Affiliation: | First Department of Internal Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu-shi Gifu 501-1194, Japan. kkimura@cc.gifu-u.ac.jp |
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| Abstract: | Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice. |
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