| 肠内营养对食管癌术后应激反应和肠道屏障功能的影响 |
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| 引用本文： | 高宗炜,马伟. 肠内营养对食管癌术后应激反应和肠道屏障功能的影响[J]. 肠外与肠内营养, 2008, 15(6): 350-353 |
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| 作者姓名： | 高宗炜 马伟 |
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| 作者单位： | 1. 临沂市人民医院胸外科,山东临沂,276003
2. 天津医科大学总医院胸部肿瘤中心,天津,300070 |
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| 摘 要： | 目的:探讨EN对食管癌病人术后应激反应和肠道屏障功能的影响. 方法:将54例食管癌切除术病人随机分成PN组(n=28例)和EN组(n=26例).分别检测手术前后不同时段的血清细胞因子、T细胞亚群、NK细胞活性、蛋白质和内毒素水平等. 结果:血清ALB、PA和FT等营养指标术后均显著降低,但两组间差异无显著性意义.术后第1和第3天,两组病人血清IL-6水平较术前均显著升高(P<0.01),EN组显著低于PN组.血清IL-10与IL-6变化相似.术后两组CD3+、CD4+、CD4+/CD8+均显著降低(P<0.01),术后第10天EN组显著高于PN组(P<0.05).术后第10天EN组NK细胞活性明显超过PN组.EN组血清内毒素水平术后显著低于PN组(P<0.05). 结论:EN支持对食管癌术后病人能减少血清内毒素、抑制过度炎症反应和维持机体免疫功能.
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| 关 键 词： | 食管癌切除术 免疫功能 应激反应 肠内营养 |
Effect of enteral nutrition on stress response and gut barrier function after esophagectomy |
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| GAO Zong-wei,MA Wei. Effect of enteral nutrition on stress response and gut barrier function after esophagectomy[J]. Parenteral & Enteral Nutrition, 2008, 15(6): 350-353 |
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| Authors: | GAO Zong-wei MA Wei |
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| Affiliation: | GAO Zong-wei1,MA Wei2(1.Department of Thoracic Surgery,Linyi People's Hospital,Linyi 276003,Sh,ong,China,2. Tianjin Medical University Cancer Institute,Tianjin 300070,China ) |
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| Abstract: | Objective:The purpose of the study was to investigate the effects of enteral nutrition on stress response and gut barrier function after surgery for esophageal cancer. Methods: Patients who underwent esophagectomy were divided into two groups. Group PN (28 patients) served as the control group. Group EN (26 patients) received enteral nutrition. Results: The serum total protein, albumin, prealbumin and transferrin decreased after operation, but there were no differences between the two groups. The serum leve... |
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| Keywords: | Esophagectomy Stress response System immune Enteral nutrition |
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