Electrical stimulation for the suppression of pathological tremor |
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Authors: | Lana Popović Maneski Nikola Jorgovanović Vojin Ilić Strahinja Došen Thierry Keller Mirjana B Popović Dejan B Popović |
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Institution: | 1.School of Electrical Engineering,University of Belgrade,Belgrade,Serbia;2.Fatronik Serbia,Belgrade,Serbia;3.Faculty of Technical Sciences,University of Novi Sad,Novi Sad,Serbia;4.Department of Health Science and Technology,Aalborg University,Aalborg,Denmark;5.TECNALIA Research & Innovation,Donostia - San Sebastian,Spain;6.Institute for Multidisciplinary Research,University of Belgrade,Belgrade,Serbia |
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Abstract: | Pathological tremor is manifested as an involuntary oscillation of one or more body parts. Tremor greatly decreases the quality
of life and often prevents the patient from performing daily activities. We hypothesized that sensors-driven multichannel
electrical stimulation could stabilize affected joints by activating the antagonistic muscles during involuntary activation
of agonist muscles and vice versa (out-of-phase stimulation). Here, we present the new system (hardware and software) and
the testing of its operation. The hardware consists of a multichannel stimulator and inertial sensors for feedback. The software
implements adaptive sensors-driven control for the out-of-phase stimulation. The system was initially applied to healthy persons
at the wrist and elbow joints to test the efficiency of the hardware and software solutions. Predefined rhythmic stimulation
resulted in tremulous movement, which subjects could not prevent; yet, they were still able to functionally use their hand.
The system was then applied to seven patients with Parkinson’s disease and essential tremor for minimization of the wrist
joint tremor. In six patients, the adaptive out-of-phase stimulation resulted in a significant decrease in the amplitude of
tremor (67 ± 13%). In one patient, the stimulation did not result in the expected reduction of tremor. |
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