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制备缓释微丸质量研究
引用本文:郑林,陆振举,张亦斌,邓盛齐,任静.制备缓释微丸质量研究[J].中国抗生素杂志,2012,37(4):320-324.
作者姓名:郑林  陆振举  张亦斌  邓盛齐  任静
作者单位:中国医药集团总公司四川抗菌素工业研究所,成都,610052
摘    要:缓释微丸作为缓控释药物制剂的一种形式,属于多单元型给药系统,具有一单元型给药系统不可比拟的优点,近年来随着现代制备工艺的逐渐成熟及辅料的发展,微丸已成为缓控释制剂发展的重要方向。本文以文献研究为基础,重点综述了骨架型微丸及膜控型微丸的特点以及质量研究进展,以期为微丸的进一步深入研究提供参考。

关 键 词:缓释微丸  骨架型微丸  膜控型微丸  成形特征  质量标准

Studies on the quality of preparation of sustained-release pellets
Zheng Lin , Lu Zhen-ju , Zhang Yi-bin , Deng Sheng-qi , Ren Jing.Studies on the quality of preparation of sustained-release pellets[J].Chinese Journal of Antibiotics,2012,37(4):320-324.
Authors:Zheng Lin  Lu Zhen-ju  Zhang Yi-bin  Deng Sheng-qi  Ren Jing
Institution:(China National Pharmaceutical Group Corporation,Sichuan Industrial Institute of Antibiotics,Chengdu 610052)
Abstract:As a form of controlled release drug formulations,slow-release pellets are a multi-unittype of delivery system,and is a unit-based drug delivery systems incomparable advantages.In recent years,with modern technology matures and the preparation of materials development,micro-pill has been the development of controlled release formulations become an important direction.In this paper,research-based literature,focusing on an overview of membrane control pellets and skeleton-type pellets of characteristics and quality research in order to provide a reference for further research.
Keywords:Slow-release pellets  Skeleton-type pellets  Membrane-controlled pellets  Forming characteristics  Quality standards
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