| 三七总甙对人增生性瘢痕成纤维细胞内钙离子浓度的作用 |
| |
| 引用本文： | 李文,刘剑毅.三七总甙对人增生性瘢痕成纤维细胞内钙离子浓度的作用[J].海南医学院学报,2009,15(6):542-544. |
| |
| 作者姓名： | 李文 刘剑毅 |
| |
| 作者单位： | 1. 北京军区总医院烧伤整形科,北京,10000
2. 第三军医大学西南医院整形外科,重庆,40000 |
| |
| 基金项目： | 海南医学院科研基金学报项目 |
| |
| 摘 要： | 目的：观察三七总甙对人增生性瘢痕成纤维细胞内钙离子浓度的作用。方法：体外培养人增生性瘢痕成纤维细胞，分别以400μg／mL和800μg／mLPNS处理细胞，在激光共聚焦显微镜下观察细胞内钙离子浓度的变化。结果：随着给药浓度的增加，和空白对照组相比，各给药组的细胞内钙离子浓度均有所下降（P〈0．05），两给药组之间差异也具有统计学意义（P〈0．05）。结论：三七总甙能够抑制人增生性瘢痕成纤维细胞内钙离子浓度，并具有剂量依赖效应。
|
| 关 键 词： | 瘢痕 成纤维细胞 三七总甙 钙离子 |
Effect of Panaxnotoginseng on the intracellular free calcium contentration in human hypertrophic scar fibroblasts in vitro |
| |
| LI Wen,LIU Jian-yi.Effect of Panaxnotoginseng on the intracellular free calcium contentration in human hypertrophic scar fibroblasts in vitro[J].Journal of Hainan Medical College,2009,15(6):542-544. |
| |
| Authors: | LI Wen LIU Jian-yi |
| |
| Institution: | LI Wen, LIU Jian-yi ( 1. Department of Burn and Plastic Surgery, General Hospital of Beijing Military Region Beijing 10000 ; 2. Plastic Department, Southeastern Hospital Affiliated to 3rd Military Medical University Chongqing 40000, China) |
| |
| Abstract: | Objective:To observe the effect of the panax notoginseng saponins(PNS)on the intracellular free calcium contentration in human hypertrophic scar fibroblasts in vitro.Methods:The hypertrophic scar fibroblasts were cultured in vitro and treated with PNS(400 and 800 μg/mL concentration).The intracellular free calcium concentration was investgated by confocal lasermicroscopy.Results:Compared with the control group,the intracellular free calcium concentration was inhibited significantly after PNS treatment(P<0.05),and there was significant difference between the two PNS treated groups(P<0.05).Conclusion:The PNS can inhibit the intracellular free calcium concentration in human hypertrophic scar fibroblasts with the dose-dependent manner. |
| |
| Keywords: | Scar Fibroblast Panaxnotogin seng Free calcium |
| 本文献已被 维普 万方数据 等数据库收录！ |
