反复呼吸道感染患儿细胞免疫与体液免疫检测的临床意义

目的研究反复呼吸道感染（RRI）患儿细胞与体液免疫的状态,为临床免疫治疗提供依据。方法检测42例临床确诊的反复呼吸道感染患儿外周血总T淋巴细胞、B淋巴细胞、NK细胞、CD4＋、CD8＋、CD4＋/CD8＋比值及免疫球蛋白IgG、IgA、IgM水平,并与正常健康儿童对照组比较。结果 RRI患儿的总T淋巴细胞、CD4＋细胞百分率、CD4＋/CD8＋比值较健康对照组明显减低（P〈0.05、P〈0.01、P〈0.01）,CD8＋细胞百分率明显升高（P〈0.01）;血清IgA、IgG明显减低（P〈0.05、P〈0.05）。结论 RRI患儿的细胞免疫与体液免疫功能紊乱均明显,对临床免疫治疗有一定的指导意义。

The clinic value of cellular and humoral immunity in children with recurrent respiratory tract infection

Objective To explore the cellular and immunity in children with recurrent respiratory tract infection(RRI).Methods Blood samples were taken from 42 RRI children and 40 normal Children The percentage of T-lymphocytes subsets and immunoglo-bulin IgA,IgM,IgG were measured.Results The percentage of the total lymphocytes,CD4+,CD4+/CD8+ were obviously lower than that in healthy control group(P <0.05,P <0.01,P <0.01),and CD8+ in the RRI group was higher than that in healthy control group(P <0.01).The levels of IgA and IgG in the RRI group were lower than the normal reference value(P <0.05,P <0.05).Conclusion The deficiency of T-lymphocytes and humoral immunity man be existing,and cell-mediated immune disorder is more obviously in RRI.It could guild the prevention and treatment for RRI.