| HLA与大动脉炎 |
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| 引用本文： | 丁素秋,郑德裕,尹晓丽,白峻峰. HLA与大动脉炎[J]. 中国循环杂志, 1991, 0(5) |
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| 作者姓名： | 丁素秋 郑德裕 尹晓丽 白峻峰 |
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| 作者单位： | 中国医学科学院心血管病研究所、阜外医院(丁素秋，郑德裕，尹晓丽)，中国医学科学院心血管病研究所、阜外医院(白峻峰) |
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| 摘 要： | 本文通过67例大动脉炎患者的HLA分型并经特定的数理统计分析,发现该病与A_(10);B_5;DR,等HLA抗原显著关联(Pc<0.050),并预示该病的遗传基因与HLA-DR_7-DQw_3等特定的单倍型呈显著连锁不平衡(Pc<0.010),进而阐明了该病的免疫遗传基础。
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| 关 键 词： | 大动脉炎 HLA 关联抗原 连锁不平衡单倍型 免疫应答基因 |
HLA AND AORTO-ARTERITIS |
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| Ding Suqiu,Zheng Deyu,Yin Xiaoli,et al.. HLA AND AORTO-ARTERITIS[J]. Chinese Circulation Journal, 1991, 0(5) |
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| Authors: | Ding Suqiu Zheng Deyu Yin Xiaoli et al. |
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| Affiliation: | Ding Suqiu,Zheng Deyu,Yin Xiaoli,et al. Cardiovascular Institute and Fu Wai Hospital,Chinese Academy of Medical Sciences,Beijing |
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| Abstract: | By HLA typing of 67 patients with aorto-arte ritis, it was found that the disease was associated with A_(1(?)), B_(?) and DR_7 HLA antigen (Pc>0.05) and the gene of which was shown to have linkage disequilibrium (Pc<0.01) with HLA DR_7-DQ_(ws) specific haplotype. The results provide data for the immunogenetic basis of the disease. |
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| Keywords: | Aorto-arteritis HLA associated antigen Linkage disequilibrium Immune response |
| 本文献已被 CNKI 等数据库收录！ |
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