Translational research in stroke: Taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials |
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Authors: | Marc Fisher Nils Henninger |
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Institution: | (1) Department of Neurology, University of Massachusetts Medical School, 119 Belmont Street, Worcester, MA 01605, USA |
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Abstract: | Many advances have occurred regarding an increased understanding of the basic pathophysiology of ischemic brain injury that
could lead to enhanced therapy for this disorder. Among the more important basic science advances are enhanced knowledge of
the components of the ischemic cascade, the phenomenon of ischemic preconditioning, the potential relevance of hibernation,
studies on gene expression in ischemic tissue, and imaging identification of the ischemic penumbra. The large number of unsuccessful
prior clinical trials with a wide range of purported acute stroke therapies has provided many insights and lessons regarding
how to perform better trials in the future. Translating these basic science and clinical trial design advances into effective
and safe therapies will require increased interaction and cooperation between basic scientists and clinical researchers. |
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