国产奥沙利铂联合醛氢叶酸及氟尿嘧啶治疗晚期胃癌临床研究

目的 观察国产奥沙利铂(Oxaliplatin，L-HOP)联合大剂量醛氢叶酸(CD加氟尿嘧啶(5-Fu)方案治疗晚期胃癌临床疗效及不良反应，探索晚期胃癌较合理治疗方案。方法 本研究采用CF200mg／m^2 5-FU 3g／耐持续滴注48h联合L-HOP130mg／m^2方案治疗65例晚期胃癌，对疗效及不良反应进行评价。结果 4例达完全缓解(CR)，26例达部分缓解(PR)，30例为稳定(SD)，5例为进展(PD)，有效率(CR PR)为46．2％(30／65)；中位缓解期为7个月。不良反应主要为恶心呕吐、外周静脉炎、脱发、白细胞下降、口腔溃疡、外周神经病变、腹泻等。上述不良反应绝大多数为Ⅰ-Ⅱ度反应，病人可耐受。结论 大剂量醛氢叶酸(CD加氟尿嘧啶(5-FU)静脉持续滴注联合国产奥沙利铂(Oxaliplatin，L-HOP)方案治疗晚期胃癌疗效较好，不良反应较轻，值得临床使用。

Clinical study of the effect of calcium folinate, 5-fluorouracil bolus and continuous infusion combined with oxaliplatin in the treatment of advanced gastric carcinoma

objective to observe the therapeutic effect and toxicity of high-dose-folinic acid plus 5-fluorouracil bolus and continuous infusion combined with homemade Oxaliplatin(L-HOP) in advanced gastric carcinoma. Methods 65 patients with advanced gastric carcinoma were treated with high-dose-folinic acid plus 5-fluorouracil bolus and continuous infusion 48 hours combined with Oxaliplatin. The effect of treatment, toxicity were observe. Results There were 4 complete responses, 26 partial 30 no changes and 5 progressive disease, in this objective response rate was 46.2%(30/65). The median duration was 7 months, The main side effects include?nausen and vomiting?peripheral phlebitis?alopecia?leukopenia?oral ulcer?peripheral neuritis?diarrhea. All the side effects were tolerable and mild. Conclusions The results showed that high-dose-folinic acid plus 5-fluorouracil bolus and continuous infusion combined with Oxaliplatin may be a safe and effective therapy for the patients with advanced gastric carcinoma, It was worthy of clinical administration.